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The conformational properties of the Cys‐Arg‐Glu‐Lys‐Ala (CREKA) peptide sequence labeled with fluorescein, a fluorescent dye attached to the Cys through a flexible linker have been examined using molecular dynamics simulations. The CREKA sequence has been identified as a tumor‐homing...
In this article, we describe the synthesis of a new class of oligoethylene‐glycol based water‐soluble biotin derivatives for labeling of peptides with limited solubility in aqueous solution. First 4,7,10‐trioxa‐1,13‐tridecanediamine was mono‐acetylated by succinic anhydride (Ttds)...
The human laminin α3 chain LG4 module has biological activities of cell adhesion, heparin binding, migration, and neurite outgrowth. The authors had previously identified that the active site of this protein is in residues 1411–1429 (amino‐acid sequence = KNSFMALYLSKGRLVFALG called A3G756)...
The third variable (V3) loop is an important region of glycoprotein 120 (gp120) for many biological processes, as it contains the highly conserved GPGR sequence and it represents the binding site for human immunodeficiency virus 1 (HIV‐1) antibodies and for CCR5 and CXCR4 host cell coreceptors....
DEAR EDITOR:A three‐letter code to identify homologues of the coded amino acids is proposed. The first letter is taken from the one‐letter code used for amino acids and identifies the side chain functional group that distinguishes the coded amino acid. To this is added two lower case letters...
The human epidermal growth factor receptor HER2 has emerged as an important target for molecular imaging of breast cancer. This article presents the design and synthesis of a HER2‐targeting affibody molecule with improved stability and tumor targeting capacity, and with potential use as an...
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