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The molecular basis of the tyrosine kinases binding specificity and drug resistance against cancer drugs Imatinib and Dasatinib is elucidated using Monte Carlo simulations of the inhibitor–receptor binding with the ensembles of protein kinase crystal structures. In silico proteomics analysis...
The hydration capacities of a biomimetic polymer, 2‐methacryloyloxethylphosphorylcholine polymer (pMPC), alone and microencapsulated, in association with another well known hydrating polymer, Hyaluronic acid, were investigated in vitro on skin models and in vivo on volunteers by using confocal...
Hydrogel/apatite nanocomposites are the ideal biomaterial to mimic the physio‐chemical and biologic properties of the bone and to fabricate scaffolds for bone regeneration. The objective of this work was to investigate the effect of an osteonectin derived glutamic acid sequence on the...
Chromatin is composed of genomic DNA and histones, forming a hierarchical architecture in the nucleus. The chromatin hierarchy is common among eukaryotes despite different intrinsic properties of the genome. To investigate an effect of the differences in genome organization, chromatin unfolding...
The interactions of two different porphyrins, without axial ligands—5,10,15,20‐tetrakis(1‐methylpyridinium‐4‐yl)porphyrin‐Cu(II) tetrachloride (Cu(II)TMPyP) and with bulky meso substituents—5,10,15,20‐tetrakis(N,N,N‐trimethylanilinium‐4‐yl)porphyrin tetrachloride (TMAP),...
Barley protein structure affects the barley quality, fermentation, and degradation behavior in both humans and animals among other factors such as protein matrix. Publications show various biological differences among barley varieties such as Valier and Harrington, which have significantly...
β‐Depsipeptides are β‐peptides in which one or more peptide linkages are replaced by ester linkages, resulting in a loss of a hydrogen‐bond donor (N&bond;H) and weakening of the corresponding carbonyl hydrogen‐bond acceptor moiety. The effects of three of such peptide by ester...
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