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N&bond;Ointramolecular acyl migration in Ser‐ or Thr‐containing peptides is a well‐known side reaction in peptide chemistry. It results in the mutual conversion of ester and amide bonds. Our medicinal chemistry study focused on the fact that the O‐acyl product can be readily converted to...
Second‐generation dendrimers have been prepared on solid phase by successive additions of branched polyproline building blocks starting from two different branching units anchored to the solid support. The preparation of Pro‐rich building blocks was carried out by stepwise solid‐phase...
The labeling of targeting peptides with 99mTc is a useful concept for the diagnosis of various diseases such as cancer. Although in research for at least one decade, only a very few radiopharmaceuticals based on peptides are in clinical use. The difficulty of labeling, and the resulting...
Exenatide, synthetic exendin‐4, is the first member of the incretin mimetic class of potential therapeutic agents. It has been the subject of extensive clinical trials in people with Type 2 diabetes. Results to date indicate that exenatide decreases postmeal blood glucose concentrations and...
Several studies have suggested that HIV‐1 p17 matrix protein may play an important role in AIDS pathogenesis, since anti‐p17 antibodies represent a serological marker of disease progression during HIV‐1 infection both in adults and children. Moreover, it has been recently reported that the...
The virally encoded serine protease NS3/NS4A is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma. Until very recently, the design of inhibitors for the HCV NS3 protease was...
Libraries of peptides and proteins can be categorized according to the function of their origin in gene‐ and synthetic‐based libraries. Both kinds of libraries have the potential to generate the same grade of molecular diversity, although the limits imposed by the synthetic methods have been...
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