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Although they are less abundant than their α‐analogues, β‐amino acids occur in nature both in free form and bound to peptides. Oligomers composed exclusively of β‐amino acids (so‐called β‐peptides) might be the most thoroughly investigated peptidomimetics. Beside the facts that they...
Elastic fibers are an important component of the extracellular matrix, providing elasticity and resilience to tissues that require the ability to deform repetitively and reversibly. Among the elastin‐derived peptides, the Val–Gly–Val–Ala–Pro–Gly (VGVAPG) hexapeptide is known for its...
A set of combinatorial amphipathic helical peptides referred to as the KIA series has been screened to identify native‐like helical bundles. The series contains the following consensus sequence: AKAxAAxxKAxAAxxKAGGY, where “x” positions are occupied by either Ala or Ile. The peptide...
The conformational and lipid binding properties of several calcitonin analogs were compared. These analogs were designed to have the central amphipathic helical region of salmon calcitonin and N‐ and C‐terminal segments similar to human calcitonin. The various analogs differed from one...
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