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The general anesthetics halothane and chloroform are capable of binding to synthetic water‐soluble four‐α‐helix bundles, which model the putative in vivo receptors. In this study, we investigate the binding of these anesthetics to synthetic water‐soluble three‐α‐helix bundles. A...
Spectroscopic and molecular modeling techniques have been employed to study the interaction of the oxicam group of nonsteroidal antiinflammatory drugs (NSAIDs) with a polysaccharide such as β‐cyclodextrin (β‐cd). β‐cd is a good drug delivery system and is known to reduce harmful side...
Both theory and experiments are employed to investigate the effects of small neutral osmolytes on the average intrinsic twist (l0), the torsion and bending elastic constants, and the twist energy parameter (ET) that governs the supercoiling free energy. The experimental data for ethylene glycol...
For a deeper insight into the structure of Bombyx mori silk fibroin, some model peptides containing tyrosine (Y), valine (V), and serine (S) in the basic (AG)n sequence were synthesized by the solid‐phase method and analyzed by Raman spectroscopy in order to clarify their conformation and to...
Although many viruses have been crystallized and the protein capsid structures have been determined by x‐ray crystallography, the nucleic acids often cannot be resolved. This is especially true for RNA viruses. The lack of information about the conformation of DNA/RNA greatly hinders our...
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