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We review the effect of sequence on the structure of left‐handed Z‐DNA in single crystals. The various substituent groups that define a nucleotide base as guanine, cytosine, thymine, or adenine affect both the DNA conformation and the organization of solvent around the duplex. These are...
The history of DNA crystallography is reviewed and is followed by discussion of the methods used for structure determination. The features of B‐DNA molecular and crystal structures are described. © 1997 John Wiley & Sons, Inc. Biopoly 44: 23–44, 1997
Single crystal x‐ray diffraction methods have been used to characterize numerous oligonucleotide structures, providing valuable information on the fine structure of DNA, oligonucleotide hydration, interactions with small molecule ligands and proteins. There has been a particular focus on...
All crystal structures of A‐DNA duplexes exhibit a typical crystal packing, with the termini of one molecule abutting the shallow grooves of symmetry related neighbors, while all other forms (B, Z, and RNA) tend to form infinitely stacked helices. The A‐DNA arrangement leads to the formation...
This review surveys the crystal structures between minor groove drugs and oligonucleotides, of which over thirty have now been determined. The various factors that are involved in the observed A/T sequence selectivity of these drugs are examined in structural terms. The roles of, in particular,...
The current state of three‐dimensional structure analysis of RNA by x‐ray crystallograpy is summarized. The methods of sample preparation, crystallization, data collection, and structure solution are discussed, followed by a review of the RNA structures that have been determined and of common...
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