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ABSTRACT Designing delivery agents for therapeutics is an ongoing challenge. As treatments and desired cargoes become more complex, the need for improved delivery vehicles becomes critical. Excellent delivery vehicles must ensure the stability of the cargo, maintain the cargo's solubility, and...
ABSTRACT Tryptophan (Trp) is a naturally occurring amino acid, which exhibits fluorescence emission properties that are dependent on the polarity of the local environment around the Trp side chain. However, this sensitivity also complicates interpretation of fluorescence emission data. A...
ABSTRACT A number of methods have been explored to promote the higher order assembly of collagen peptide triple helices. In one case, NCoH, a complex hierarchical metal‐promoted assembly was observed to form micron‐scaled florettes with a ruffled surface topology at the nanoscale. In an...
ABSTRACT Förster resonance energy transfer (FRET) has been widely used as a spectroscopic tool in vitro to study the interactions between transmembrane (TM) helices in detergent and lipid environments. This technique has been instrumental to many studies that have greatly contributed to...
ABSTRACT Signaling across the cell membrane mediated by transmembrane receptors plays an important role in diverse biological processes. Recent studies have indicated that, in a number of single‐span transmembrane receptors, the intracellular juxtamembrane (JM) sequence linking the...
ABSTRACT Protein−protein interactions (PPIs) are critical in numerous biological processes including signaling transduction, function regulations, and disease development. To regulate PPIs has been thought to be challenging due to their highly dynamic and expansive interfacial areas....
ABSTRACT Building on the pioneering work of Ho and DeGrado (J Am Chem Soc 1987, 109, 6751–6758) in the late 1980s, protein design approaches have revealed many fundamental features of protein structure and stability. We are now in the era that the early work presaged – the design of new...
ABSTRACT The helix length dependence of the stability of antiparallel four‐chain coiled coils is investigated using eight synthetic peptides (Lac21–Lac28) whose sequences are derived from the tetramerization domain of the Lac repressor protein. Previous studies using analytical...
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