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Praziquantel derivatives with activity against both juvenile and adult Schistosoma j . in vitro.
A new proline-rich cyclic octapeptide named stylissamide X was isolated from an Indonesian marine sponge of Stylissa sp. as an inhibitor of cell migration from the guidance of wound-healing assay.
The synthesis and SAR of epiminocyclohepta( b )indole analogs as 5-HT 6 antagonists are described.
Graphical abstract The discovery of 3,6-epoxy (1,5)dioxocines as potential antifilarial agents is described. The most active compound 4f showed promising in vitro as well as in vivo antifilarial activity.
A catechin, pilosanol N inhibited NO production in LPS-stimulated macrophages through involved both NO scavenging and suppression of i NOS expression.
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