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Objective : XRCC4 play a key role in nonhomologous end-joining repair pathway. Alterations in DNA repair gene have been shown to reduce DNA repair capacity thereby inflicting carcinogenesis. Methods : In a hospital-based case-control study, 192 prostate cancer (PCa) and 224 healthy controls. They...
We investigated the utility of 1,6-hexamethylene diamine (HDA) hemoglobin adducts as biomarkers of exposure to 1,6-hexamethylene diisocyanate (HDI) monomer. Blood samples from 15 spray painters applying HDI-containing paint were analyzed for hemoglobin HDA (HDA-Hb) and N -acetyl-1,6-hexamethylene...
The purpose of this paper is to identify immunologic hallmarks of excessive bodyweight. The analysis is based on 176 adults (106 women, 70 men) who participated in a nested case-control study in Italy. All participants were healthy at the time of blood collection and aged between 36 and 75 years....
Background : MRproADM and MRproANP can be used as diagnostic and prognostic markers in heart failure. Aim : The objective was to identify confounding factors for the interpretation of plasma MRproADM and MRproANP concentrations. Methods : A total of 518 healthy volunteers with a mean age of 60.84...
Context : The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results : Models of blood cotinine regressed against...