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Abstract The mini-chain of human cathepsin H has been identified as the major structural element determining the proteases substrate specificity. A genetically engineered mutant of human cathepsin H lacking the minichain, des(Glu(-18)-Thr(-11))-cathepsin H, exhibits endopeptidase activity towards...
Abstract All epithelia form sheets of cells connected by tight and adherent junctions and exhibit polarized distribution of membrane proteins and lipids. During their development, epithelia progress from this 'generic' phenotype to terminally differentiated states characterized by the development...