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Biological Chemistry Volume 384 Issue 2

Subject Areas: Biochemistry; ;
Publisher: Walter de Gruyter - de Gruyter
ISSN: 1431-6730
SJR: 123

LitStream

Journal Article

Cystatins C, E/M and F in Human Pleural Fluids of Patients with Neoplastic and Inflammatory Lung Disorders

Werle, B.; Sauckel, K.; Nathanson, C.-M.; Bjarnadottir, M.; Spiess, E.; Ebert, W.; Abrahamson, M.

2003 Biological Chemistry

doi:10.1515/BC.2003.031 pmid:12675521

Abstract Secretory type 2 cystatins, like cystatins C, E/M and F, are thought to be involved in many pathobiological processes, including vascular amyloidosis, rheumatoid arthritis, Alzheimers disease, osteoporosis, viral and bacterial infections, inflammatory disorders and tumour invasion and...
LitStream

Journal Article

Identification of Cytosolic Leucyl Aminopeptidase (EC 3.4.11.1) as the Major Cysteinylglycine-Hydrolysing Activity in Rat Liver

Jösch, C.; Klotz, L.-O.; Sies, H.

2003 Biological Chemistry

doi:10.1515/BC.2003.023 pmid:12675513

Abstract Cysteinylglycine hydrolysis is a step in the metabolism of glutathione and glutathione S-conjugates. We had previously observed that in rat liver the enzymatic activity is predominantly located in the cytosol. Here we demonstrate that cytosolic leucyl aminopeptidase (EC 3.4.11.1) is the...
LitStream

Journal Article

Transcriptional Repression of the Human p53 Gene by Hepatitis B Viral Core Protein (HBc) in Human Liver Cells

Kwon, J.A.; Rho, H.M.

2003 Biological Chemistry

doi:10.1515/BC.2003.022 pmid:12675512

Abstract Hepatitis B virus (HBV) is a causative agent of chronic and acute hepatitis, and is associated with the development of hepatocellular carcinoma (HCC). We demonstrate here that the Hepatitis B viral core protein (HBc) functions as a repressor on the promoter activity of the human p53...
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Journal Article

Obituary

2003 Biological Chemistry

doi:10.1515/bchm.2003.384.2.191
LitStream

Journal Article

Modifications of Glyceraldehyde-3-Phosphate Dehydrogenase Induced by Increasing Concentrations of Peroxynitrite: Early Recognition by 20S Proteasome

Buchczyk, D.P.; Grune, T.; Sies, H.; Klotz, L.-O.

2003 Biological Chemistry

doi:10.1515/BC.2003.026 pmid:12675516

Abstract Peroxynitrite, a potent oxidizing and nitrating species, induces covalent modifications of biomolecules in a number of pathological conditions. In previous studies with S. cerevisiae, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was identified as being especially susceptible to...
LitStream

Journal Article

A Novel Influenza A Virus Activating Enzyme from Porcine Lung: Purification and Characterization

Sato, M.; Yoshida, S.; Iida, K.; Tomozawa, T.; Kido, H.; Yamashita, M.

2003 Biological Chemistry

doi:10.1515/BC.2003.024 pmid:12675514

Abstract Proteolytic activation of hemagglutinin, an envelope glycoprotein of the influenza virus, by host proteases is essential for infection and proliferation of the virus. However, there is no well-defined, inherent source of host proteases in man or swine, both of which are natural hosts for...
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Journal Article

A Homodimeric Sporamin-Type Trypsin Inhibitor with Antiproliferative, HIV Reverse Transcriptase-Inhibitory and Antifungal Activities from Wampee (Clausena lansium) Seeds

Ng, T.B.; Lam, S.K.; Fong, W.P.

2003 Biological Chemistry

doi:10.1515/BC.2003.032 pmid:12675522

Abstract A homodimeric trypsin inhibitor with a molecular mass of 54 kDa was isolated from the seeds of Clausena lansium (Lour) Skeels with a very simple procedure comprising extraction with an aqueous buffer and ion exchange chromatography on CM-cellulose. It inhibited trypsin with an IC50 of...
LitStream

Journal Article

A Bioinformatic Approach to the Identification of Candidate Genes for the Development of New Cancer Diagnostics

Musumarra, G.; Barresi, V.; Condorelli, D.F.; Scirè, S.

2003 Biological Chemistry

doi:10.1515/BC.2003.037 pmid:12675527

Abstract A multivariate analysis of the National Cancer Institute gene expression database is reported here. The soft independent modelling of a class analogy approach achieved cell line classification according to histological origin. With the PCA method, based on the expression of 9605 genes...

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