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Escherichia coli lipoproteins are anchored to the periplasmic surface of the inner or outer membrane depending on the sorting signal. An ATP-binding cassette (ABC) transporter, LolCDE, releases outer membrane-specific lipoproteins from the inner membrane, causing the formation of a complex...
Glucocorticoids induce apoptosis in lymphocytes by causing the release of cytochrome c into the cytosol; however, the events in the signaling phase between translocation of the steroid–receptor complex to the nucleus and the release of cytochrome c have not been elucidated. Previously, we found...
The protein machinery that mediates homotypic fusion of mammalian endoplasmic reticulum (ER) membranes is becoming increasing well defined. However, little is known of how acylation of constituent membrane components might impact upon this event. This is particularly important as acylation has...
Disintegrins, low molecular weight RGD-containing polypeptides isolated from snake venoms, have seen use as integrin antagonists in the field of tumor biology and angiogenesis. In this study, we investigated the molecular mechanism by which the disintegrin echistatin affects cell adhesion and...
To address the function of the Golgi- and nuclear envelope-localized spectrin family member synaptic nuclear envelope protein-1 (Syne-1), we expressed two separate recombinant fragments derived from the central portion of the molecule. Both of these fragments were predicted to act as dominant...
Oxaline and neoxaline, fungal alkaloids, were found to inhibit cell proliferation and to induce cell cycle arrest at the G 2 /M phase in Jurkat cells. CBP501 (a peptide corresponding to amino acids 211–221 of Cdc25C phosphatase), which inhibits the G 2 checkpoint, did not affect the G 2 /M...
Oxidative stress and apoptosis are implicated in tendon degeneration. Peroxiredoxin 5 (PRDX5) is a novel thioredoxin peroxidase recently identified in mammals, participating directly in eliminating hydrogen peroxide (H 2 O 2 ) and neutralizing other reactive oxygen species (ROS). We have...
Tri- n -butyltin (TBT), a biocide, is known for its immunotoxicity and hepatotoxicity and is a well-characterised mitochondrial toxin. This report investigates the mechanisms involved in induction of apoptosis by TBT in primary cultures of rat hepatocytes. Release of cytochrome c from...
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