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Cricetomys gambianus are rodents living in savanna and follow area. They can live with restricted drinking water eating fresh food. Therefore their kidney may have some adaptive mechanisms for ion/water homeostasis compared to usual laboratory rats. In this study we have looked for calbindin, an...
S100β is a calcium binding protein expressed primarily by astrocytes in the brain. In initiating studies of the toxic signalling pathways activated by high concentrations of S100β, we previously demonstrated thetreatment of astrocytes with μM S100β results in a potent stimulation of the mRNA...
Annexin II is a growth-regulated gene, whose expression is significantly increased in various human cancers. We examined annexin II expression in 11 human B-cell lymphoma cell lines and in normal B-cells. Wide variation was observed in the levels of annexin II in these cell lines. Annexin II...
Understanding the processes and events that occur when a cell undergoes a prelethal injury or that lead the cell to death following a lethal injury has been the aim of our research for a number of years. Throughout this period much has been learned, recently at rapid rates, not only by us but my...
The binding of heme-CO to genetically engineered calmodulin containing a single tryptophan residue has been studied. A tryptophan residue was integrated at one of five positions: 26 or 62 of the N-terminal, 81 in the central helix, or 99 or 135 of the C-terminal. As for the wild type, the mutant...
The Ca 2+ -binding protein S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and has been shown to interact with SR-proteins regulating the Ca 2+ -induced Ca 2+ -release. We, therefore, hypothesized that changes in S100A1 gene expression might correlate with...
We have investigated the interaction of S-100 proteins (β and/or α) and annexin II 2 -p11 2 with glial fibrillary acidic protein (GFAP) and desmin to have further information on the mechanisms whereby S-100 proteins and annexin II 2 -p11 2 affect assembly/disassembly of GFAP and desmin...
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