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Highlights ► A422T mutation in HERG channel loss of function. ► The protein of A422T has trafficking defect, resulting in ER retention. ► A422T mutation is rescurable by pharmacologic or molecular chaperones.
Highlights ► The frequency of CD4 + CXCR5 + CCR6 + T cells increased in pSS patients and positively correlated with autoantibodies in the blood. ► CD4 + CXCR5 + CCR6 + T cells in blood invariably coexpressed PD-1, ICOS, CD40L, Bcl-6 and secreted IL-21 after stimulated by PHA. ► CD4 + CXCR5...
Highlights ► FasL-bound planar lipid bilayer as a novel model cell membrane. ► Cells interacting with the FasL-bound bilayer form submicron Fas–FasL microdomains. ► The Fas–FasL microdomains are structurally stable for several hours. ► After the Fas–FasL microdomain formation, rapid...
Highlights ► A novel soluble TCR composed of TCR V and C regions with Ig Fc region is generated. ► TCR-Fc protein immobilized by an anti-Cβ antibody bound to a p/MHC tetramer. ► Binding affinity of TCR-Fc was markedly increased by binding with anti-Cβ antibody.
Highlights ► αvβ3 and αvβ5 integrins bind the human CD23 protein via an RKC motif. ► The interaction of αv integrins and CD23 is cation-independent. ► Single substitutions in RKC do not abolish integrin binding or biological function. ► Integrin binding of RKC and RGD motifs have...
Highlights ► SOX9 inhibits myocardin-induced smooth muscle gene transcription. ► SOX9 does not interfere with SRF binding to the CArG box. ► SOX9 does not interact with SRF but associates with myocardin. ► Myocardin suppresses Sox9-induced Col2a1 promoter activities. ► There is an...
Highlights ► ZapA of Proteus mirabilis and LasB of Pseudomonas aeruginosa are virulence factors. ► N -alpha mercaptoamide inhibitor analogues have been designed and synthesized. ► Active site properties of ZapA and LasB have been further characterized. ► Inhibitor binding preferences of...
Highlights ► Phenylbutyric acid induces cellular senescence. ► Phenylbutyric acid activates Akt kinase. ► The knockdown of PERK also can induce cellular senescence. ► Akt/p21 WAF1 pathway activates in PERK knockdown induced cellular senescence.
Highlights ► Mutated LPA 1 stimulates cell migration of endothelial cells. ► VEGF expressions are increased by mutated LPA 1 . ► LPA signaling via mutated LPA 1 is involved in angiogenesis. ► Mutated LPA 1 promotes cancer cell progression.
Highlights ► The murine calvaria-derived cells share similar morphological features with MSCs. ► The murine calvaria-derived cells share similar surface antigens with MSCs. ► But the calvaria-derived cells highly express the transcription factor osterix. ► The calvaria-derived cells lose...
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