Within the last year
Within the past 3 years
1 - 10 of 26 articles
Highlights ► A422T mutation in HERG channel loss of function. ► The protein of A422T has trafficking defect, resulting in ER retention. ► A422T mutation is rescurable by pharmacologic or molecular chaperones.
Highlights ► The frequency of CD4 + CXCR5 + CCR6 + T cells increased in pSS patients and positively correlated with autoantibodies in the blood. ► CD4 + CXCR5 + CCR6 + T cells in blood invariably coexpressed PD-1, ICOS, CD40L, Bcl-6 and secreted IL-21 after stimulated by PHA. ► CD4 + CXCR5...
Highlights ► FasL-bound planar lipid bilayer as a novel model cell membrane. ► Cells interacting with the FasL-bound bilayer form submicron Fas–FasL microdomains. ► The Fas–FasL microdomains are structurally stable for several hours. ► After the Fas–FasL microdomain formation, rapid...
Highlights ► A novel soluble TCR composed of TCR V and C regions with Ig Fc region is generated. ► TCR-Fc protein immobilized by an anti-Cβ antibody bound to a p/MHC tetramer. ► Binding affinity of TCR-Fc was markedly increased by binding with anti-Cβ antibody.
Highlights ► αvβ3 and αvβ5 integrins bind the human CD23 protein via an RKC motif. ► The interaction of αv integrins and CD23 is cation-independent. ► Single substitutions in RKC do not abolish integrin binding or biological function. ► Integrin binding of RKC and RGD motifs have...
Highlights ► SOX9 inhibits myocardin-induced smooth muscle gene transcription. ► SOX9 does not interfere with SRF binding to the CArG box. ► SOX9 does not interact with SRF but associates with myocardin. ► Myocardin suppresses Sox9-induced Col2a1 promoter activities. ► There is an...
Highlights ► ZapA of Proteus mirabilis and LasB of Pseudomonas aeruginosa are virulence factors. ► N -alpha mercaptoamide inhibitor analogues have been designed and synthesized. ► Active site properties of ZapA and LasB have been further characterized. ► Inhibitor binding preferences of...
Highlights ► Mutated LPA 1 stimulates cell migration of endothelial cells. ► VEGF expressions are increased by mutated LPA 1 . ► LPA signaling via mutated LPA 1 is involved in angiogenesis. ► Mutated LPA 1 promotes cancer cell progression.
Highlights ► Phenylbutyric acid induces cellular senescence. ► Phenylbutyric acid activates Akt kinase. ► The knockdown of PERK also can induce cellular senescence. ► Akt/p21 WAF1 pathway activates in PERK knockdown induced cellular senescence.
Highlights ► The murine calvaria-derived cells share similar morphological features with MSCs. ► The murine calvaria-derived cells share similar surface antigens with MSCs. ► But the calvaria-derived cells highly express the transcription factor osterix. ► The calvaria-derived cells lose...
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don't already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don't already have one.
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don't already have one.