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Highlights ► DACH1 increases cyclin D, F and Cdk 1, 4, 6 in mouse myeloid progenitor cells. ► The knockdown of DACH1 blocked the cell cycle progression of HL-60 cells. ► The novel effect of DACH1 related with cell cycle regulation and leukemogenesis.
Highlights ► Osteocyte incubation with IL-1β stimulated osteocyte-modulated osteoclastogenesis. ► Conditioned medium from IL-1β-treated osteocytes increased osteoclastogenesis. ► IL-1β upregulated RANKL and downregulated OPG gene expression by osteocytes. ► CYR61 is upregulated in...
Highlights ► The crystal structure of the NTF2-like domain of Rasputin protein is presented. ► Differences to known ligand binding sites of nuclear transport factor 2 are discussed. ► A new ligand binding site for the Rasputin and G3BP proteins is proposed.
Highlights ► IL-17 deficiency reduced atherosclerosis in Western diet-fed apoE −/− mice. ► IL-17 deficiency decreased the expression of cytokines and scavenger receptors. ► IL-17 upregulated the expression of IL-12 p40 and IL-6 in macrophages.
Highlights ► N -glycosylation was induced at Asn 2 of Hsp30p by severe heat shock. ► N -glycosylation of Hsp30p was not induced by mild heat shock and glucose depletion. ► N -glycosylation affects the physiological roles of Hsp30p upon severe heat shock. ► N -glycosylation has little...
Highlights ► Cyld deficiency suppresses pro-inflammatory phenotypic switch of VSMCs. ► Cyld deficiency inhibits MAPK rather than NF-kB activity in inflamed VSMCs. ► CYLD is up-regulated in the coronary artery with neointimal hyperplasia.
Highlights ► Rsf-1 expression is elevated in non-small cell lung cancers. ► Rsf-1 depletion inhibits proliferation and increased apoptosis in lung cancer cells. ► Rsf-1 depletion decreases the level of cyclinD1 and phosphor-ERK expression.
Highlights ► Universal binding of Nutlin-3 with diverse anti-apoptotic Bcl-2 family proteins. ► Nutlin-3 binds to the BH3 peptide-binding grooves of Bcl-2 family proteins. ► A conserved Bcl-X L binding mechanism of the Nutlin-3 and BH3-mimetic compounds. ► A molecular basis for the...
Highlights ► The interaction of amyloid beta-peptide (1–40)(Aβ 40 ) with surfactants is described. ► The secondary structure of Aβ 40 depends on the surfactant concentration and charge. ► Only charged micelles can induce α-helix structure on Aβ 40 . ► If electrostatic interactions...
Highlights ► We investigate the interaction of GLP-1 and leptin on feeding. ► Coinjection of subthreshold of these two hormones significantly decreases feeding. ► Coinjection of these two hormones dramatically decreases AMPK in the hypothalamus. ► Coinjection of these two hormones...
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