Within the last year
Within the past 3 years
1 - 10 of 40 articles
Highlights ► ParaAT is a parallel tool for constructing multiple protein-coding DNA alignments. ► ParaAT is capable of parallelly processing a large number of homologs. ► ParaAT provides good scalability and significant reduction in running time. ► ParaAT is well suited for large-scale...
Highlights ► TOP levels in striatum, hippocampus and cortex of cocaine treated rats were measured. ► Increased TOP activity was observed in the striatum of cocaine treated rats. ► qRT-PCR showed that this increase is due to newly synthesized TOP.
Highlights ► High serum levels of S100A8/A9 complex in obesity. ► Circulating S100A8/A9 complex levels correlated significantly with abdominal adiposity. ► High S100A8 mRNA levels in mature adipocyte fraction of obese mice. ► High S100A9 mRNA levels in stromal vascular cell fraction of...
Highlights ► Trimethylation of histone H3K4 is important for transcriptional regulation of fructose responsible genes in rat jejunum. ► The first report of fructose responsible genes in adult rats. ► Fructose enhances expression of genes related to signal transduction in rat jejunum.
Highlights ► The effect of a newly developed S1P 1 -selective antagonist on angiogenic responses. ► S1P 1 is a critical component of VEGF-related angiogenic responses. ► S1P 1 -selective antagonist showed in vitro activity to inhibit angiogenesis. ► S1P 1 -selective antagonist showed in...
Highlights ► RNA interference GPC3 induces apoptosis in human hepatocellular carcinoma cell. ► Silencing GPC3 resulted in the release of cytochrome c and activation of caspase-3. ► GPC3 modulates the Bax/Bcl-2/cytochrome c /caspase-3 apoptotic signaling pathway. ► Knockdown of GPC3 is a...
Highlights ► Tetrahydrobiopterin is an essential cofactor for hydroxylation reaction of cyclic amino acids. ► A novel method is developed to measure intact BH4 and dopamine by using LC–MS/MS. ► This method improves significantly assay performance for BH4 and dopamine in brain. ► It can...
Highlights ► DNA methylation is dynamic and flexible and changes rapidly upon cell activation. ► DNA methylation controls the inducible gene expression in a given cell type. ► Some enzymes are involved in maintaining the methylation profile of immune cells.
Highlights ► XPD up-regulated the expressions of P53, phospho-P53(ser-15), P21. ► XPD down-regulated the expressions of Bcl-2 and HBx. ► XPD inhibited the viability of HepG2.2.15 and exacerbated the apoptosis. ► Pifithrin-α, Inhibitor of P53, abolished above-mentioned effects of XPD.
Highlights ► Sensorineural hearing loss is the most prevalent human genetic sensory defect. ► Mutations in the TMPRSS3 cause two forms of non-syndromic recessive deafness. ► We performed a genetic analysis of TMPRSS3 gene in 80 Moroccan deaf families. ► Nineteen variants were found which...
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one.
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.