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Highlights ► ParaAT is a parallel tool for constructing multiple protein-coding DNA alignments. ► ParaAT is capable of parallelly processing a large number of homologs. ► ParaAT provides good scalability and significant reduction in running time. ► ParaAT is well suited for large-scale...
Highlights ► TOP levels in striatum, hippocampus and cortex of cocaine treated rats were measured. ► Increased TOP activity was observed in the striatum of cocaine treated rats. ► qRT-PCR showed that this increase is due to newly synthesized TOP.
Highlights ► High serum levels of S100A8/A9 complex in obesity. ► Circulating S100A8/A9 complex levels correlated significantly with abdominal adiposity. ► High S100A8 mRNA levels in mature adipocyte fraction of obese mice. ► High S100A9 mRNA levels in stromal vascular cell fraction of...
Highlights ► The effect of a newly developed S1P 1 -selective antagonist on angiogenic responses. ► S1P 1 is a critical component of VEGF-related angiogenic responses. ► S1P 1 -selective antagonist showed in vitro activity to inhibit angiogenesis. ► S1P 1 -selective antagonist showed in...
Highlights ► Trimethylation of histone H3K4 is important for transcriptional regulation of fructose responsible genes in rat jejunum. ► The first report of fructose responsible genes in adult rats. ► Fructose enhances expression of genes related to signal transduction in rat jejunum.
Highlights ► Tetrahydrobiopterin is an essential cofactor for hydroxylation reaction of cyclic amino acids. ► A novel method is developed to measure intact BH4 and dopamine by using LC–MS/MS. ► This method improves significantly assay performance for BH4 and dopamine in brain. ► It can...
Highlights ► RNA interference GPC3 induces apoptosis in human hepatocellular carcinoma cell. ► Silencing GPC3 resulted in the release of cytochrome c and activation of caspase-3. ► GPC3 modulates the Bax/Bcl-2/cytochrome c /caspase-3 apoptotic signaling pathway. ► Knockdown of GPC3 is a...
Highlights ► DNA methylation is dynamic and flexible and changes rapidly upon cell activation. ► DNA methylation controls the inducible gene expression in a given cell type. ► Some enzymes are involved in maintaining the methylation profile of immune cells.
Highlights ► XPD up-regulated the expressions of P53, phospho-P53(ser-15), P21. ► XPD down-regulated the expressions of Bcl-2 and HBx. ► XPD inhibited the viability of HepG2.2.15 and exacerbated the apoptosis. ► Pifithrin-α, Inhibitor of P53, abolished above-mentioned effects of XPD.
Highlights ► Sensorineural hearing loss is the most prevalent human genetic sensory defect. ► Mutations in the TMPRSS3 cause two forms of non-syndromic recessive deafness. ► We performed a genetic analysis of TMPRSS3 gene in 80 Moroccan deaf families. ► Nineteen variants were found which...
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