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Highlights ► Foenumoside B was isolated from Lysimachia foenum-graecum . ► Foenumoside B inhibited adipogenesis and shifted lipid metabolism toward lipolysis. ► Foenumoside B activated AMPK. ► Foenumoside B improved high-fat diet-induced obesity in mouse. ► Foenumoside B has a...
Highlights ► Luteolin potentiates TRAIL-induced apoptosis in cultured A549 cells and HeLa cells. ► Luteolin enhances TRAIL’s antitumor activity in a lung cancer xenograft mouse model. ► Luteolin enhances TRAIL’s in vivo antitumor activity through enhancing apoptosis.
Highlights ► TQ can induced gastric cancer cells apoptosis in vitro and in vivo. ► TQ can decrease bcl-2, increase bax, release cyt-c, active caspase-3 and caspases-9. ► TQ can augments 5-FU-induced apoptosis. ► TQ can increase the chemosensitisation of gastric cancer to 5-FU.
Highlights ► Spiral artery (SA) remodeling (SAR) is ill-defined but clinically important. ► Timing of SA formation and identification of SAR timing and mode in mice. ► Two types of SAR occur during early mouse postimplantation. ► Both SAR types are not associated with invasive trophoblast...
Highlights ► Pan-neuronal JNK knockdown reduces sleep and longevity in Drosophila . ► JNK heterozygous knockout flies show a reduction in sleep. ► JNK knockdown flies show a normal arousal threshold and rebound sleep. ► Lifespan of JNK knockdown is short, and even shorter on a low calorie...
Highlights ► We examine whether ER Ca 2+ -binding protein calumin modulates CRAC channel activity. ► Co-expression of calumin with Orai1 does not form CRAC channel. ► Calumin is directly associated with Orai1 and STIM1. ► Ca 2+ permeability of CRAC channels is decreased when co-expressed...
Highlights ► GacA and iron coordinately control virulence traits in Pseudomonas syringae pv. tabaci 11528. ► P. syringae pv. tabaci 11528 GacA affects lesion formation on tobacco leaves. ► Expression of the virulence genes is regulated by GacA.
Highlights ► Coexpression of β-catenin increased voltage-gated kV current in Kv1.5 expressing oocytes. ► The effect was not dependent on the stimulation of transcription. ► β-catenin enhances the membrane abundance of Kv1.5. ► β-catenin fosters insertion of Kv1.5 protein into the...
Highlights ► Mutated LPA 1 increases the induction of Mmp-2 expression. ► The activation of Mmp-2 is enhanced by mutated LPA 1 . ► Mutated LPA 1 increases progression of tumor cells. ► LPA signaling is involved in MMP induction.
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