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Highlights ► Als2 and UXT proteins interact both in vitro and in vivo . ► Als2 and Uxt proteins co-localizes in cultured neuroblastoma Neuro2A cells. ► Als2 and Uxt transcriptional levels are directly correlated through cell cycle.
Highlights ► We identified PRKRIR as a novel interaction partner of RIG-I. >PRKRIR augments type I IFN synthesis mediated by RIG-I. ► The stability of RIG-I protein is increased by PRKRIR. ► PRKRIR inhibits poly-ubiquitination of RIG-I. ► PRKRIR inhibits the viral replication through the...
Highlights ► As a target of oncogene RhoA-linked signal, a prostaglandin metabolism is assessed. ► RhoA activation increases PGE 2 levels and its metabolic enzyme mPGES-1. ► RhoA-activated NF-κB and EGR-1 are positively involved in mPGES-1 induction.
Highlights ► Endogenous CnA and CnB have a statistically significant relationship. ► Point mutation of CnB M118 influences its interaction with subunit A. ► CnB M118K does not change the expression level of CnA, but decreases its activity. ► Point mutation CnB M118 may act a marker in...
Highlights ► Hypothalamic cell model that expresses clock genes, AgRP and NPY . ► Excess palmitate directly alters the rhythmic gene expression of clock genes and NPY . ► AMPK inhibition causes a decrease in both basal and palmitate-treated NPY transcription. ► AMPK activator, AICAR,...
Highlights ► Npc1 mutation was transferred from the BALB/c to C57BL/6J inbred background in mice. ► C57BL/6J -Npc1 −/− mice present with a much more aggressive form of the disease. ► C57BL/6J -Npc1 −/− mice had a shorter lifespan and striking spleen damage. ► Genetic background...
Highlights ► Obesity induced by high-fat diet decreased ghrelin expression in macrophages. ► Exercise training recovered the obesity-induced reduction of ghrelin in macrophages. ► Ghrelin functioned as a negative regulator of TNF-α expression in macrophages. ► Ghrelin suppressed...
Highlights ► Numblike and Numb are highly conserved mammalian homologs to Drosophila Numb. ► Numblike and Numb differ with regard to control of p53 and Sonic Hedgehog signaling. ► Generation of a mouse embryonic stem cell line with inducible expression of Numblike.
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