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Highlights ► EGF and its receptor translocates to the nucleus in liver cells. ► Real time imaging shows that EGF moves to the nucleus. ► EGF moves with its receptor to the nucleus. ► Dynamin and clathrin are necessary for EGFR nuclear translocation.
Highlights ► Hv1 is specifically expressed in highly metastatic human breast tumor tissues. ► Hv1 regulates breast cancer cytosolic pH. ► Hv1 acidifies extracellular milieu. ► Hv1 exacerbates the migratory ability of metastatic cells.
Highlights ► DU145 prostate cancer cell line was isolated into CD44+ or CD44− cells. ► We confirmed CD44+ DU145 cells are more proliferative and tumorigenic than CD44− DU145 cells. ► We analyzed and identified proteins that were differentially expressed between CD44+ and CD44− DU145...
Highlights ► Upon prolonged mitosis, cells undergo p53-dependent mitotic catastrophe. ► p62-deficient cells were resistant to mitotic catastrophe. ► p53 stabilization was attenuated in p62-deficient cells upon prolonged mitosis. ► Non-canonical activation of Nrf2 by p62 was required for...
Highlights ► We solved the structure of α-neoagarobiose hydrolase of Saccharophagus degradans 2–40 ( Sd NABH). ► Both a native and ligand ( d -galactose) complex of Sd NABH were determined. ► The position of bound ligand implies the +1 subsite of substrate in the binding pocket. ►...
Highlights ► A novel epsilon isoform of nesprin-2 has been discovered. ► This 120 kDa protein was predicted by bioinformatic analysis, but has not previously been observed. ► It is the main isoform expressed in a teratocarcinoma cell line and is also found in ovary. ► Like other nesprins,...
Highlights ► MELK expression significantly increased when the cells are exposed to radiation or 5-FU. ► Suppression of MELK caused cell cycle changes and decrease in proliferation. ► Radiation or 5-FU treatment after MELK suppression by siRNA induced growth inhibition.
Highlights ► GSH facilitates the base-off transition of vitamin B 12 induced upon binding to bCblC. ► GSH increases the binding affinity for vitamin B 12 . ► Binding of GSH induces changes in the conformation of bCblC.
Highlights ► Substrate recognition by UDP-GalNAc 4-epimerases is analyzed using sitedirected mutants. ► Most of the single point mutants retain the activity similar to the wild-type enzyme. ► Structure of the His305Ala mutant suggests the substrate-binding site to be fairly elastic. ►...
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