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Research highlights ► Activation of PPARδ by GW501516 significantly inhibited Ang II-induced premature senescence in hVSMCs. ► Agonist-activated PPARδ suppressed generation of Ang II-triggered ROS with a concomitant reduction in DNA damage. ► GW501516 up-regulated expression of...
Highlights ► α-TT but not α-TP inhibits RANKL expression in osteoblasts. ► α-TT inhibits RANKL-induced osteoclastogenesis by suppressing c-Fos expression in precursors. ► α-TT suppresses RANKL-induced ERK and delayed NF-κB activation. ► α-TT but not α-TP reduces bone-resorbing...
Highlights ► Glioblastoma stem cells (GSCs) display elevated invasive capacity in vitro . ► GSCs are more invasive than matched non-stem tumor cells in vivo . ► GSCs increase expression of invasion-associated proteins including L1CAM. ► L1CAM is highly expressed in GSCs and the invasive...
Research highlights ► The thermal stability of pig Na,K-ATPase is larger than that of shark Na,K-ATPase. ► Native pig lipids are less fluid than native shark lipids. ► Purification and reconstitution in native lipids did not affect thermal stability. ► 9-fold dilution with exogenous...
Research highlights ► In this study, we investigated the effects of leptin on adipocyte differentiation prepared from subcutaneous fat of TallyHo mice. ► Leptin inhibited the adipocytes differentiation at physiological concentration via inhibition of PPARγ expression. ► Inhibitors of ERK...
Research highlights ► IDH1 mutations are early and frequent genetic alterations in gliomas. ► We newly established an anti-IDH1-R132S-specific mAb SMab-1. ► SMab-1 reacted with the IDH1-R132S peptide, but not with other IDH1 mutants. ► SMab-1 specifically stained the IDH1-R132S-expressing...
Research highlights ► NDRG2 was downregulated in colorectal cancer. ► NDRG2 was direct target of miR-650. ► Hypermethylation and miR-650 regulated the expression of NDRG2.
Research highlights ► Up to 80% of patients with advanced cancers are affected by cancer cachexia accounting for nearly 30% of cancer-related deaths. ► The toxicity of chemotherapeutic drugs in normal cells is a serious problem with significant side effects on cancer treatment. ► The...
Research highlights ► Proteomic analysis of wobbler mouse model of amyotrophic lateral sclerosis confirms atrophy-related changes in skeletal muscle. ► Fluorescence difference in-gel electrophoresis reveals alterations in 24 muscle-associated proteins in wobbler mouse. ► Altered proteins...
Research highlights ► Mode of operation of specific endo β-1–3 acting glucanase. ► Biophysical characterization over laminarase hyperthermophilicity. ► Low resolution determination by small angle X-ray of a V-shape laminarase.
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