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Research highlights ►Sindbis, an oncolytic virus, causes translational shut-off, and inactivates eIF2α. ► Rapamycin, torin1 do not affect replication. ► PI3K/Akt/mTOR is not required, and suppressed by infection. ► Time dependent virus and drug effects on Akt/mTOR. ► mTOR suppression...
Research highlights ► The secondary structure of AZ contains 51% β-sheet, 19% α-helix, and 24% coils. ► The association constant ( K A ) between yeast AZ and yeast ODC is 6 × 10 7 (M −1 ). ► We have isolated inactive ODC:AZ inhibitory complex for the first time. ► The MW of the...
Research highlights ► SMT3IP1 interacts with p53 and Mdm2, and desumoylates both proteins. ► SMT3IP1 competes with p53 for binding to the central acidic domain of Mdm2. ► SMT3IP1 binding to Mdm2 inhibits Mdm2-mediated p53 ubiquitination and degradation. ► We postulate that SMT3IP1 acts as...
Research highlights ► Divalent metal cation binds to chondroitin sulfate with different efficiencies. ► Chondroitin sulfate metal salts as donors regulate hyaluronidase transglycosylation. ► Barium enhances the transglycosylation of hyaluronidase. ► Zinc inhibits the transglycosylation of...
Research highlights ► Study expression of RNA-editing enzyme ADAR1 isoforms in pediatric acute leukemia. ► The expression features of two isoforms (p110 and p150) were different. ► Over expression of p110 in B-ALL and decrease of p110 at CR stage. ► The expression of both p110 and p150...
Research highlights ► Epigallocatechin-3-gallate (EGCG) is an ATP-competitive inhibitor of PI3K and mTOR with Ki values around 300 nM. ► EGCG inhibits cell proliferation and AKT phosphorylation at Ser473 in MDA-MB-231and A549 cells. ► Molecular docking studies show that EGCG binds well to...
Research highlights ► Acerogenin A stimulated osteoblast differentiation in osteogenic cells. ► Acerogenin A-induced osteoblast differentiation was inhibited by noggin. ► Acerogenin A increased Bmp-2 , Bmp-4 and Bmp-7 mRNA expression in MC3T3-E1 cells. ► Acerogenin A is a candidate agent...
Highlights ► TIM-1 is highly expressed on anti-IgM + anti-CD40-stimulated B cells. ► Anti-TIM-1 mAb enhanced proliferation and Ig production on activated B cell in vitro. ► TIM-1 signaling regulates Ab production by response to TI-2 and TD antigens in vivo.
Research highlights ► Explore co-expression of TGFβ1/VEGF 165 gene transfer on ACL graft remodeling. ► TGFβ1/VEGF 165 -gene-transfected BMSCs promote angiogenesis. ► Co-expression achieves the best mechanical properties of the grafts. ► Cross-talk between TGFβ1 and VEGF 165 accelerate...
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