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Research highlights 13 SNPs were associated with BD independently of HLA-B ∗ 51 and -A ∗ 26 . ►Stepwise logistic regression analysis indicated that 2 SNPs are associated with BD among these. ►rs9261365 locates on near the region in 14-kb upstream of RNF39 . ►rs2074474 locates on exon 9...
Research highlights ► Overexpression of Abba increases the dorsal ruffling mediated by PDGF. ► Abba activates Rac1 upon PDGF stimuli. ► PDGF treatment increases the association of Abba with Rac1. ► The Abba’s I-BAR domain is regulated by its C-terminal sequence.
Research highlights ► Cholesterol treatment prevented PrP (106–126)-mediated neuronal cell death. ► Cholesterol treatment inhibited PrP (106–126)-induced ROS generation. ► PrP (106–126)-mediated increase of p53 were blocked by cholesterol treatment. ► PrP (106–126)-mediated...
Research highlights ► Through the BRET approach the existence of D 2L R-5-HT 2A R heteromers in living cells and its functional consequences is demonstrated. ► The 5-HT 2A R-mediated PLC activation and rise of intracellular calcium levels are synergistically enhanced by coactivation of the D...
Research highlights ► Visualizing low abundant cancer relevant tyrosine phosphorylated proteins. ► Requirements for applied fluorescent Western blotting and 2-D DIGE. ► Imatinib-induced changes in tyrosine phosphorylation to leukemia cells detected. ► Non-overlapping spot pattern of total...
Research highlights ► Proteasome inhibition during cold ischemia of hearts prolongs myocardial viability. ► Proteasome inhibition during cold ischemia of hearts reduces reperfusion injury. ► Proteasome inhibition during cold ischemia has direct cardioprotective effects. ► Proteasome...
Research highlights ► This paper provides the first evidence that luxS deletion enhances swimming motility and flagella synthesis in Escherichia coli K12 based on motility, transcriptome, and scanning electron microscopy analyses. ► A conceptual genetic regulatory network underlying the...
Research highlights ► Neural stem cells are able to differentiate into Schwann-like cells; ► Schwann-like cells express S100 and p75 proteins; ► Schwann-like cells promote neurite outgrowth.
Research highlights ► Skn-1a markedly downregulates ΔNp63-driven K14 expression. ► ΔNp63 inhibits Skn-1a-mediated K10 expression. ► ΔNp63, mutated in SAM domain, is less effecting in K10 downregulation. ► Immunolocalization in human skin of the two transcription factors is partially...
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