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Research highlights ► Orexin neurons display heterogeneous miniature EPSCs with fast and slow kinetics. ► Fast and slow miniature EPSCs arise from different synapses. ► AMPA receptors mediate both fast and slow mEPSCs. ► Fast and slow mEPSCs are equally modulated by dopamine.
Research highlights ► Our results demonstrate that exposure of cells to UDCA decreased the half-life of p53, while slightly increasing proteasome activity. ► More importantly, when we chemically inhibited proteasome activity, pre-treatment with UDCA resulted in increased accumulation of...
Research highlights ► Synergistic action of riboflavin and UVA or UVB caused extensive degradation of all the five bases of DNA and RNA. ► The guanine derivatives were equally sensitive to photosensitization. ► The extent of degradation by riboflavin was more than the recognized...
Research highlights ► Exogenous VEGF decreases MRP4 expression in a dose-dependent manner. ► MRP4 knockdown leads to enhanced cell migration. ► MRP4 knockdown suppresses caspase-3-mediated cell apoptosis. ► MRP4 knockdown produces cell assembly and cell aggregation.
Research highlights ► The precartilage condensation mediated by N-cadherin is essential for chondrocyte differentiation. ► The biochemical significance of cleavage of N-cadherin in chondrocyte differentiation is not fully understood. ► We examined the significance of cleavage of N-cadherin...
Research highlights ► Cyclic AMP induces plasminogen activator inhibitor-1 (PAI-1) expression in mast cells (MCs). ► The cAMP-response element-binding protein is the key transcription factor. ► The hypoxia response element-1 at −158/−153 bp is the pivotal cis-acting element. ► Cyclic...
Research highlights ► The expression of Mel-18, a mammalian polycomb homologue, was induced during the differentiation of endothelial progenitor cell (EPC) into endothelial cells (EC) in vitro . ► Mel-18 accelerates EPC differentiation into EC and promotes angiogenic activity of ECs in vitro...
Research highlights ► Mouse adipose derived mesenchymal stem cell differentiation. ► Efficiently differentiate into vascular endothelial cells in vitro. ► The cells are differentiate in serum-free condition. ► FGF2 is a key molecule in this differentiated culture.
Research highlights ► Formation of the α-synuclein amyloid fibrils by (BIMbF 3 Im). ► Disaggregation of amyloid fibrils by epigallocatechin gallate (EGCG) and baicalein. ► Amyloid formation of α-synuclein tandem repeat (α-TR).
Research highlights ► 2M4VP activated the expression of p21 and p15 protein, and down-regulated the expression of cyclin D1 and cyclin E. ► 2M4VP inhibited hyper-phosphorylation of Rb protein. ► 2M4VP induced cell cycle arrest from G1 to S. ► 2M4VP inhibited hyper-proliferation of the...
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