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Amplification and overexpression of murine double minute (MDM2) has been observed in several human cancers. Some chemotherapeutic agents cause MDM2 ubiquitination and degradation in a proteasome-dependent system. In addition to the proteasome system, chaperone-mediated autophagy (CMA) is a...
Research highlights ► Performed a large-scale siRNA competition potency analysis. ► Sequence features that predict competition potency of siRNAs were identified. ► Competition potency of siRNAs is specified by the 5′-half antisense sequence.
Research highlights ► One known homozygous mutation (Y258X) was identified. ► Two heterozygous missense variants (P305A and E476K) was identified. ► Thirteen polymorphisms of which five were novel were identified. ► No homozygous exonic deletions were detected. ► PINK1 is not a common...
Research highlights ► Identification of sodium channel β3 subunit gene SCN3B as a new gene responsible for atrial fibrillation, which is the most common cardiac rhythm disturbance in the clinical setting, accounts for more than 15% of strokes, and is associated with worsening heart failure and...
Research highlights ► FimA fimbriae are an important virulence factor of Porphyromonas gingivalis . ► FimA fimabriae have been reported to stimulate cells via TLR2. ► Degeneration of the protein up-regulated TLR2-mediated TNF-α production in macrophage. ► Enhanced stimulatory activity of...
Extensive studies over the years have shown that the AMP-activated kinase (AMPK) exhibits negative regulatory effects on the activation of the mammalian target of rapamycin (mTOR) signaling cascade. We examined the potential involvement of AMPK in the regulation of growth and survival of...
Deregulation of E2F1 activity is characteristic of gastric tumorigenesis, which involves in complex molecular mechanisms. microRNA is one of the post-transcriptional regulators for gene expression. Here, we report a member of miR-331 family, miR-331-3p, which was decreased in some kinds of...
Research highlights ► Akt, ERK, and p38 pathways are involved in SDF-1-induced hUCB-MSC migration. ► SDF-1 activates Akt, ERK, and p38 signal transduction pathways in hUCB-MSCs. ► Knockdown of Akt, ERK, and p38 inhibits SDF-1-induced migration of hUCB-MSCs. ► PI3K, ERK, and p38 inhibitors...
Research highlights ► DFO-induced hypoxia increased GSH and HIF-1α levels in hypoxia-surviving neurons. ► DFO decreased hMOR gene expression at the transcription level. ► The CT element located at the active hMOR promoter partially mediated DFO response.
Limited proteolysis of APOBEC-1 complementation factor (ACF) and computational secondary structure modeling were used to guide the construction of a well-folded, truncation protein spanning residues 1–320 and containing three RNA recognition motifs (RRMs) . ACF320 bound preferentially to apoB...
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