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Highlights ► Lesion to the anterolateral BNST blunted the attenuation in weight gain during a chronic stress paradigm. ► The blunted response was apparent only in the last few days of stress. ► Data suggests multiple mechanisms for stress-induced anorexia.
Highlights ► We examine the effect of the chemotherapy drug oxaliplatin on cognition. ► We use fear conditioning, extinction and fear renewal in laboratory rats. ► Oxaliplatin did not affect context- or CS-fear conditioning, or extinction. ► Oxaliplatin reduced renewed fear to an...
Highlights ► TLE patients with HS have reduced postcentral gyrus size. ► TLE patients with HS are severely impaired in a virtual egocentric memory task. ► Smaller postcentral gyrus size is related to worse egocentric task performance. ► Egocentric task impairment may indicate significant...
Highlights ► Learning performance is similar for active and observational feedback learning. ► The anterior caudate nucleus is activated more strongly for active learning. ► The medial orbitofrontal cortex is activated more strongly for active learning. ► Hippocampal activity is enhanced...
Highlights ► Subchronic PCP dosing is a rat model for psychosis without tolerance effects. ► PCP causes impaired LTP in amygdala and hippocampus and impaired extinction of fear memory. ► PCP causes increased NMDA/AMPA receptor mediated currents in the amygdala. ► PCP causes decreased...
Highlights ► Estrogen affects brain activities, but little is known about the pathways involved. ► We measured rodent activity and amygdala 5-HT and DA levels in OVX and sham rats. ► OVX reduced dark-phase but not light-phase activity or the circadian rhythm. ► The levels of 5-HT and DA...
Highlights ► Novel operant assay for zebrafish which may be used to assess attention and impulse control. ► Low-dose d -amphetamine reduces premature responding in zebrafish. ► Potential to utilize mutant lines to screen for endophenotypes for addiction.
Highlights ► Adh1 −/− and Adh1 / 4 −/− mice have higher spontaneous activity compared to WT mice. ► Apomorphine increase locomotor activity in Adh1 −/− and Adh1 / 4 −/− mice. ► d- Amphetamine increase locomotor activity in Adh1 −/− and Adh1 / 4 −/− mice. ► Adh1...
Highlights ► A rat model of depression is developed by exogenous CORT administration. ► TGP reverses depressive-like behavior in CORT-treated rats. ► TGP increases BDNF protein levels in the hippocampus and frontal cortex of CORT-treated rats.
Highlights ► MyD88 deficiency in mice increases anxiety in the elevated plus-maze. ► MyD88 deficiency in mice slows movement in the stationary beam and coat hanger tests. ► MyD88 deficiency in mice enhances spatial learning performance in Morris water maze. ► MyD88 deficiency ameliorates...
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