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Highlights ► GluA1 AMPAR subunit is important for short-term recognition memory. ► We tested whether GluA1 is necessary for short-term memory in trace conditioning. ► GluA1 deletion impaired rewarded alternation, but not trace conditioning. ► The dissociation may reflect processing of...
Highlights ► The corticospinal system sets the spatial frame of reference for motor action. ► This subthreshold control strategy predetermines motor response to perturbation. ► Corticospinal pathways facilitate antagonist motoneurons in preparation to perturbation. ► Corticospinal control...
Highlights ► Lavender oil may have anxiety-reducing properties, but experimental studies are few. ► The oil had some of chlordiazepoxide's effects on open field behaviour. ► c-fos expression was raised by open field test in 8 anxiety-related brain areas. ► Chlordiazepoxide reversed this...
Highlights ► Repeated treatment with the NOS inhibitor l -NAME alone produced a dual effect on rats’ recognition memory abilities. ► l -NAME counteracted delay-dependent recognition memory deficits. ► The effects of l -NAME on memory are dependent on the treatment conditions rather than...
Highlights ► Cognitive models suggest that attention is progresses through space in s salience-based fashion. ► Biological models do not agree on which neural pathway generates visual salience. ► The nasal-temporal asymmetry in salience-based progression of attention was investigated. ►...
Highlights ► ICV STZ caused memory impairment in rat alongwith oxidative stress in the brain. ► Nicotine treatment attenuated mitochondrial dysfunction and caspase-3 activity. ► Mitochondrial dysfunction and increase in caspase-3 activity was found in rat brain. ► Central nicotinic...
Highlights ► MK-801 given pre-training hindered memory formation. ► Atypical antipsychotics, sulpiride and olanzapine, improved MK-801-induced amnesia. ► MK-801 produced social interaction deficit. ► Atypical antipsychotics reversed the MK-801-induced social interaction deficit.
Highlights ► Disturbed plasticity is considered to underlie the pathophysiology of schizophrenia. ► Transcranial magnetic stimulation and transcranial direct current stimulation allow the investigation of cortical plasticity to awake humans. ► Schizophrenia patients showed an impaired...
Highlights ► First study to examine an in vivo characterization of a point mutation in Rtn4r in the mouse as it related to the development of schizophrenia. ► Behavioural assays included prepulse inhibition of acoustic startle, locomotor activity, social interaction and spatial cognition. ►...
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