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T and B lymphocytes are central regulators and effectors of immune responses and are believed to have a key role in many autoimmune diseases. Targeting the activation or effector function of lymphocytes is a potentially effective approach to treat autoimmunity. Typically, T-cell activation occurs...
The inflammatory bowel diseases ulcerative colitis and Crohn's disease (CD) are heterogeneous syndromes representing the outcome of the colliding influences of shared and distinct genetic risk factors, environmental or lifestyle modifiers and immune effector mechanisms. Identification of specific...
There is a need for methods to improve the diagnosis, patient staging and evaluation of therapeutic response in patients with autoimmune conditions to improve patient care. Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are two inflammatory diseases characterized by involvement of...