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When MRL/Mp - + / + (MRU +) mice are lethally irradiated and then reconstituted with MRL/Mp-lpr/lpr (MRL/lpr) spleen and/or bone marrow cells (BMCs), the mice develop a graft-versus-host disease (GVHD)-like syndrome which is known as lpr-GVHD. We analyzed lpr-GVHD by adoptive transfer experiments...
To study the mechanisms involved in the pathogenesis of the blood- brain barrier (BBB) breakdown in autoimmune demyelinating diseases, such as experimental allergic encephalomyelitis (EAE), we investigated the cell interaction in vitro between myelin basic protein (MBP)- specific encephalitogenic...
We investigated the relative roles of B cell activity, circulating immune complexes, complement concentration and kinetics of disappearance and uptake of immune complexes from the circulation in the pathogenesis of early nephritis of MRL/lpr mice. In comparison to data in control (C57BL/6J) mice,...
Research in immunology and adjacent disciplines during recent years have given rise to many new concepts. The findings of new cytokines evoke hope for new treatment modalities, although the ideas have to be confirmed by trials involving human beings to settle what is right and what is wrong. Data...