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Previous studies have demonstrated a stimulatory effect of interleukin-1β (IL-1β) on insulin and glucagon release from the perfused rat pancreas, accompanied by selective lysis of 20% of β-cells as assessed by electronmicroscopy. However, we have not observed an inhibitory action of IL-1β on...
Systemic vasculitis is an inflammatory disorder of blood vessels characterized by a perivascular mononuclear cell infiltration around the vessel and fibrinoid necrosis within vessel walls. Interleukin-I (IL-I) is a multipotent inflammatory mediator and affects several properties of vascular...
To better define the relationships between circulating autoantibodies and renal involvement in systemic lupus erythematosus (SLE), antibodies to both dsDNA and soluble cellular antigens were detected in sera from a large series of SLE patients. Significantly higher dsDNA binding activities and...
The expression of major histocompatibility complex class II molecules (Ia antigen) has been analyzed by immunoperoxidase staining in thyroids of normal C3H mice, of iodine-deficient mice with a hyperplastic goiter and of mice during goiter involution induced by administration of either a high...
We tested sera and purified immunoglobulin (Ig) fractions from patients with autoimmune thyroid disorders (AITD), with and without ophthalmopathy, and normal subjects, for the presence of antibodies reactive with eye muscle membrane antigens in an optimized enzyme-linked immunosorbent assay...
There are three distinct and well characterized thyroid autoantigens-thyroglobulin (Tg), thyroid peroxidase (microsomal antigen/TPO) and the TSH receptor. Auto-antibodies to the TSH receptor are responsible for hyperthyroidism in Graves' disease whereas antibodies to TPO and Tg are associated...
The purpose of this study was to examine longitudinally the different patterns of nuclear and cytoplasmic antigen recognition by sera from patients with SLE during clinical flare and remission using immunoblot-ting (1B) techniques. Serum samoles ( n = 150) were obtained from 35 SLE Datients...
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