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Glucose oxidase(GOD) was immobilized on agrose(a) by diazo-tization using p(β-sulfate-ethylfonyl aniline(SESA) as cross-linking agent, (b) by a new improved glutaraldehyde method and (c) by polyacrylamide entrapment. Results showed that GOD immobilized by the improved glutaraldehyde method had...
Intraperitoneal injections of para-Chlorophenylalanine methyl ester and Phenylalanine solution were used to produce phenylketonuria in rats. By the use of different diets and orally administered Phenylalanine ammonia lyase (PAL) loaded artificial cells, the Phenylalanine concentration gradient...
Scientists, businessmen, universities and industries with fundamental or peripheral interests in technology as applied to life processes will be keenly interested in recent U.S. Patent Office decisions. These decisions indicate that new higher life forms, animal or plant, are proper subjects of...
In order to selectively remove pathogenic macromolecular reactants, a biological affinity type adsorbent (a DNA colloidin charcoal column or protein A sepharose CL4R = Prosorba) has been developed and used for the treatment of immune disorders, alloimmunization and cancer. However, because...
Site binding constants, calculated for the adsorption of bilirubin onto various lysine, arginine, or histidine containing oligopeptide-resins assuming either a one or two site binding model, are of the order of 104 M . Using these data it can be shown that there are positive cooperative effects...
Controlled-release polymeric needle devices containing adriamycin HCL (ADH) were investigated by an in vitro dissolution study in normal saline solution and an in vivo antitumor activity in C3H mice bearing mammary carcinoma and nude mice bearing brain tumor. HPMC was used as a release rate...
Hemolysate-loaded liposomes were prepared with their surfaces coated by polysaccharides, carboxymethylchitin, carboxymethyl-cellulose and carboxymethylchitosan. Phagocytosis by guineapig polymorphonuclear leukocytes of these coated liposomes was measured in view of electrostatic interactions...
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