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In the hope of obtaining useful probes to study the structure of human apolipoprotein B (apo B), we characterized monoclonal antibodies against low density lipoprotein (LDL). We examined the distribution of their corresponding antigenic determinants on tryptic fragments of LDL separated by...
An initial exposure to high concentrations of free fatty acid increased the transfer of albumin across cultured endothelial monolayers. The rate and amount of albumin transfer was dependent on the oleic acid concentration to which the cultures were initially exposed, with 300 μM producing the...
Cholesterol-enriched, apolipoprotein E-containing high density lipoproteins (apo E HDLc), which were Isolated from the plasma of cholesterol-fed dogs by using agarose column chromatography or ultracentrlfugatlon, possessed essentially Identical biochemical and metabolic characteristics....
The effect of diet-induced moderate hypercholesterolemia on endothelial healing has been investigated in the rabbit following a narrow superficial injury to aortic endothelium without damage to the media of the vessel. The healing process was compared with that observed in normocholesterolemic...
The possibility that low high density lipoprotein (HDL) levels may add to the risk of occlusive atherosclerosis in familial hyperchoiesteroiemia (FH) is supported by the frequency and severity of this finding in these patients, particularly homozygotes. To investigate this abnormality in greater...
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