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A highly purified protein that facilitates the exchange and net mass transfer of cholesteryl ester (CE), and trlacylglycerol (TG), and the transfer of phosphatldylchollne (PC), between plasma llpoprotelns was isolated from the d-1.21-1.25 g/ml plasma fraction. Transfer activities showed similar...
The mechanisms for the hypocholesterolemic action of neomycin were examined in six patients with various levels of plasma total cholesterol and triglycerides. All patients were studied on a metabolic ward. The first period of 6 weeks was for control. Thereafter, neomycin (1.5 g/day) was started,...
Prostacyclin (PGI2) and prostaglandin E2(PGE2) production was Investigated in human aortas (five controls and 27 with atherosclerotic lesions). The specific activities of PGI2and PGE2synthetase were studied using radioimmunoassays of PGE2and 6-keto-PGE1α, of aortic microsomes incubated in the...
High levels of neutral triglyceride lipase activity have been demonstrated In several types of macrophages (J774 cells, human monocyte/macrophages, rabbit alveolar macrophages, and resident mouse peritoneal macrophages). The pH optima ranged from 6.5 to 7.4 depending upon the buffer and the...
To further understand the hormonal mechanisms linking behavior pattern and coronary artery disease (CAD), we Investigated the relationship between 0930-hour plasma cortisol and cholesterol In relatively young males who had undergone coronary anglography and In a subgroup of Individuals who had...
Endothelium was isolated from samples of aorta and vena cava obtained from cadaver donors at the time kidneys were harvested for transplantation. Digestion with collagenase and gentle swabbing were used to free the cells from the Intlmal surface. Low density seeding permitted isolation of...
Endothelial cells In vivo come Into contact with fibrin during numerous physiological and pathological processes, but the nature of this Interaction Is poorly understood. The Interaction of fibrin and endothelial cells was examined by Incubating bovine aortic endothelial cell monolayers in vitro...
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