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The powerful vasoconstrictor peptide endothelin-1 (ET1) has been shown to reduce local cerebral blood flow in brain areas supplied by the middle cerebral artery (MCA) to a pathologically low level upon intracerebral injection adjacent to the MCA. This reduction manifests itself as an ischemic...
Eighty five patients suffering from trigeminal neuralgia resistant to medical therapy underwent surgical treatment for relief of pain at the Department of Neurosurgery University Alexander Hospital Sofia from 1981 until 1997. Microvascular decompression at the root entry zone of the V th nerve...
The constitutional elements of the mototrigeminal nucleus in man are described. Apart from the well-known a motoneurons, interneurons and γ motoneurons can be discerned. Cortical projections to the mototrigeminal nucleus in man arise both ipsilateral and contralateral. The contralateral...
In this study the effect of dexamethasone on the motoneuronal cell death and the nuclear and somatic morphology changes occurring after peripheral nerve transection in the neonatal rats has been determined. The study was performed on 3 day old Wistar rats. Animals were divided into 3 groups –...
The presence and distribution of two calcium-binding proteins (CaBPs), parvalbumin (PV) and calbindin D-28k (CB) were immunohistochemically examined in the mesencephalic trigeminal nucleus (MTN) of normal untreated cats and after peripheral nerve injury to the masseteric nerve. Under normal...
Tyr-MIF-1 is a representative of the MIF‘s family of endogenous peptides. It has been isolated from bovine hypothalamus and human parietal cortex that suggests its involvement in nociception. Tyr-MIF-1 can bind to the µ-receptors as well as to its specific non-opiate receptors in the brain....
Several amino acids may function as neurotransmitters in the nervous system. The potential role of glutamate (Glu) and aspartate in excitatory responses was demonstrated and it was established that GABA and glycine act as inhibitory agents. The present study aimed at investigating the...
The primary sensory trigeminal system in birds comprises the mesencephalic trigeminal nucleus and the trigeminal ganglion with projections to the principal sensory nucleus (PrV) and the descending tract with its subnuclei. Other cranial nerves can contribute to PrV and the descending system that...
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