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A bioassay-guided fractionation of the CH 2 Cl 2 extract of Selaginella tamariscina yielded six sterols 1–6 such as (4α, 5α)-4, 14-dimethylcholest-8-en-3-one ( 1 ), ergosta-4, 6, 8(14), 22-tetraene-3-one ( 2 ), ergosterol endoperoxide ( 3 ), 7β-hydroxycholesterol ( 4 ), 7β-hydroxysitosterol...
We have previously reported that live Bifidobacterium longum SPM1207, a strain isolated from healthy adult Koreans, significantly reduced serum cholesterol in broth and rat. We here examined the effect of oral administration of sonication-killed B. longum SPM1207 on serum cholesterol in rats in...
Twenty five compounds including ten triterpenes ( 1–3, 5–11 ), six flavonoids ( 12–15, 24, 25 ), five lignans ( 17, 18, 21–23 ), two butenyl clohexnone glycosides ( 19–20 ), one fructofuranoside ( 16 ) and one fatty acid ( 4 ) were isolated from the roots of Ulmus davidiana var....
To examine drug synergism between angiotensin II AT1-receptor blocker and Ca 2+ channel blocker for lowering blood pressure (BP), telmisartan and lercanidipine were orally injected into to telemetered-spontaneous hypertensive rats and BP was monitored. The highest doses of both drugs (7.66 mg/kg...
Stereoisomers of nadolol were derivatized with S-(-)-menthyl chloroformate((-)-MCF) forming their diastereomers, RSR-nadolol-(-)-MCF, SRS-nadolol-(-)-MCF, RRS-nadolol-(-)-MCF and SSRnadolol-(-)-MCF. Diastereomeric mixture were then chromatographically resolved by preparative HPLC...
A global analysis of the chemical space of cytochrome P450 enzymes in humans has not been achieved despite its great importance for drug metabolism and drug-drug interactions. We analyzed the global characteristics of cytochrome P450s by building several networks at the family, subfamily, and...
The knowledge of protein functions as well as structures is critical for drug discovery and development. The FEATURE system developed at Stanford is an effective tool for characterizing and classifying local environments in proteins. FEATURE utilizes vectors of a fixed dimension to represent the...
New 15-keto-prostaglandins ( 1 – 4 ) were isolated from the MeOH extract of the red alga, Gracilaria verrucosa . Their structures were determined to be prostaglandin B congeners ( 1 – 3 ) and a prostaglandin E congener ( 4 ) based on the NMR and MS data. Prostaglandins with a C-15 keto...
The present study aims to investigate the effects of prednisolone on the pharmacokinetics of orally and intravenously administered loratadine in rats. A single dose of loratadine was administered orally (4 mg/kg) and intravenously (1 mg/kg) in the presence or absence of prednisolone (0.2 or 0.8...
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