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From the leaves of Brassica juncea , three kaempferol glycosides, kaempferol-3- O -(2- O -sinapoyl)-β- d -glucopyranosyl-(1→2)-β- d -glucopyranoside-7- O -β- d -glucopyranoside ( 1 ), kaempferol-3- O -β- d -glucopyranosyl-(1→2)-β- d -glucopyranoside-7- O -β- d...
The present work deals with the anticancer effect of benzimidazole derivatives associated with the pyridine framework. By varying the functional group at N -terminal of the benzimidazole by different L-amino acids, several 2-(4-(2,2,2-trifluoroethoxy)-3-methylpyridin-2-ylthio)-1 H...
The aim is to study the effect of dimethylsulfoxide-soluble smoking particles (DSP) and nicotine on the contractility of rat mesenteric artery. The superior mesenteric artery segments were cultured with DSP or nicotine for 24 h. The vascular contractibility was recorded with myograph system. DSP...
Gefitinib is an anti-cancer drug that selectively inhibits epithelial growth factor receptor (EGFR) tyrosine kinase activity and induces apoptosis in many cancer cells. Cancer cells are often protected from apoptotic cell death by telomerase, however the gefitinib-induced telomerase inhibition...
The aim of this study was to provide a basis for examining the molecular mechanism for the pharmacological action of ethanol. Energy transfer between the surface fluorescent probe 1-anilinonaphthalene-8-sulfonic acid and hydrophobic fluorescent probe 1,3-di(1-pyrenyl)propane was used to examine...
Pure enantiomers are of large interest for several industries. This study was aimed to establish a method for separation of etodolac enantiomers by preferential crystallization after a conglomerate formation of its derivatives. S-(+)-etodolac and R-(−)-etodolac enantiomers were both prepared by...
By various chromatographic methods, one new phenylpropanoid glycoside, heterosmilaside ( 1 ), two known phenylpropanoid glycosides, helonioside B ( 2) , and 2′,6′-diacetyl-3,6-diferuloyl sucrose ( 3 ), and three known flavonoids, isoquercetin ( 4 ), quercetin-3- O - β -D-glucuronopyranoside...
This study was to investigate the effect of lovastatin on the bioavailability or pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats. The pharmacokinetic parameters of verapamil and norverapamil in rats were measured after the oral administration of verapamil (9 mg/kg)...
Mountainous vegetables called chwinamul are used in Korea to promote health. Chwinamul was obtained from several plants belonging to the Compositae — e.g., Kalimeris yomena, Aster scaber, Solidago virga var. gigantea, Solidago viragaurea var. asiatica, Saussurea grandifolia, Ainsliaea...
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