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The alteration in the pharmacokinetic behaviors of organic cations (OCs) in rats during acute inflammation (Al) was investigated. Al was induced by an intraperitoneal injection of lipopolysaccharide (LPS, 5 mg/kg) 24 hr prior to the start of pharmacokinetic studies. Tributyl-methylammonium...
Four diarylheptanoids, (5R)-1,7-bis (3,4-dihydroxyphenyl)-heptane-5-O-β-D-glucoside ( 1 ), (5R)-1,7-bis (3,4-dihydroxyphenyl)-heptane-5-ol ( 2 ), oregonin ( 3 ), hirsutanonol ( 4 ), were isolated from the bark of Alnus hirsuta Turcz and its inhibitory effects on melanogenesis by measuring the...
Four new acetylated ginsenosides were isolated from the processed ginseng (SG, sun ginseng). Their structures were determined to be 3β,12β-dihydroxydammar-20(22),24-diene-3-O-β-D-glucopyranosyl(1→2)-P-D-6″-O-acetylglucopyranoside; 3β,12β-dihydroxydammar-20(21),...
The demand for new alternative “low calorie” sweeteners for dietetic and diabetic purposes has increased worldwide. Although the currently developed and commercially used highly sweet sucrose substitutes are mostly synthetic compounds, the search for such compounds from natural sources is...
Monocytes and macrophages play a major role in defense mechanism of the host response to tumor, in part through the secretion of several potent products and macrophage cytokines. Monocytes and tissue macrophages produce at least two groups of protein mediators of inflammation, interleukin 1...
A series of novel exomethylene cyclopropyl nucleosides have been synthesized starting from Feist’s acid. Classical nucleophilic substitution conditions (K 2 CO 3 , 18-crown-6) of the tosylate 2 as well as Mitsunobu reaction (DEAD, PPh 3 ) of alcohol 1 with pyrimidine bases afforded a series of...
The airway surface liquid (ASL), often referred to as mucus, is a thin layer of fluid covering the luminal surface of the airway. The major function of mucus is to protect the lung through mucociliary clearance against foreign particles and chemicals entering the lung. The mucus is comprised of...
Four flavonoid glycosides, flavaprin ( 7 ), evodioside B ( 8 ), vitexin ( 11 ), and hesperidin ( 12 ), as well as the coumarins bergapten ( 1 ), xanthotoxin ( 2 ), and isopimpinellin ( 3 ), the lignan simplex-oside ( 10 ), the steroids β-sitosterol ( 4 ) and daucosterol ( 5 ), the limonoids...
The pharmacokinetic of paclitaxel (1 mg/kg, i.v.) was investigated in rabbits with carbon tetra-chloride-induced hepatic failure. The area under the plasma concentration-time curve (AUC) of paclitaxel was significantly (p<0.01) increased in severe carbon tetrachloride-induced hepatic failure...
In the course of finding Korean natural products for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the roots of Angelica dahurica showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the...
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