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The effects of Eurycoma longifolia Jack were studied on the sexual behaviour of male rats. Sexually normal male rats were treated twice daily with 500 mg kg −1 of different fractions of E. longifolia Jack for 10 days prior to test and were then observed for their copulatory behaviour with a...
Effects of swainsonine (SW; 8α, β-indolizidine-1α, 2α, 8-triol from Locoweed) on the humoral immune responses of lipopolysaccharide (LPS) were studied in ICR mice. Mice were divided into 4 groups (10mice/group), and LPS was given to each mouse 1 hr after i.p. injection with 3.7 mg/kg of...
The 6,6-dibromopenam 6 was treated with CH 3 MgBr and carbaldehyde 5 to afford the 6-bromo-6-(1-hydroxy-1-methyl)penicillanate 7 , which was reacted with acetic anhydride to give acetoxy compound 8 . The deacetobromination of 8 with zinc and acetic acid gave 6-exomethylenpenams, Z-isomer 9 and...
A CHCl 3 : MeOH extract of the fruit of Lycium chinense Mill. (Solanaceae) was found to afford significant protection against carbon tetrachloride-induced toxicity in primary cultures of rat hepatocytes. Subsequent activity-guided fractionation resulted in the isolation of zeaxanthin and...
The 1 H-NMR signals of 2-cephems and 3-cephems have been assigned and the Nuclear Overhauser Effect (NOE) study of these compounds was undertaken.
Some new 9H-thioxanthen-9-one incorporated into heterocyclic systems such as pyridone 8 , pyrazoline 9 , pyranone 11 , iminopyrane 12 , furopyrimidine 17 , imidazothiazole 19 , thiazole 21 , triazine 24 and other related compounds through a para imminophenyl grouping at position-1 of the...
Chlorambucil is known to alkylate primarily N7 of guanine and N3 of adenine to induce DNA monofunctional adducts and interstrand cross-links (ISC). We have investigated the sequence specificity for DNA ISC induced by chlorambucil using duplex oligomers containing a difined cross-linkable...
The pharmacokinetics of YH439 and its metabolites were investigated after oral administration of YH439 to rats to investigate the food effect. After oral administration of YH439, its metabolites, M4 and M5 were detected in plasma. YH439 was not detected in the plasma for both fasted and fed rats...
Steroid 9α-hydroxylase is a key enzyme system in steroid nucleus degradation in company with Δ 1 -dehydrogenase. To examine 9α-hydroxylase activity during microbial transformation of steroids, 9(11)-dehydro-17α-methyl-testosterone was adopted as a stable substrate for preventing the rupture...
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