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An imbalance in human leucocyte elastase (HLE) activity is widely recognized to play an important pathological role in a number of human diseases. An earlier report has described greater transcription of elafin, an endogenous inhibitor of HLE, in epithelia of odontogenic keratocysts of the jaw...
Muscarinic cholinergic stimulation of submandibular acinar cells results in the activation of Ca 2+ -dependent ion-transport pathways responsible for the secretion of primary saliva. Decreased saliva production is common among elderly people and may compromise oral health with implications for...
Defence reactions of the dental pulp potentially involve a variety of immunocompetent cells, particularly class II major histocampatibility complex (MHC)-expressing cells and macrophages. In order to examine how the immunodefence potential of the pulp changes as a function of age, phenotypic...
Gingival crevicular fluid (GCF) contains several different proteinase activities and the study sought to clarify their sources. Gingival tissue and GCF were collected from chronic periodontitis patients. Gel-filtration chromatography of crude tissue extracts yielded cathepsin B and tryptase...
Bacterial lipopolysaccharides possess bone-resorbing activity. Here, lipopolysaccharides from three putative periodontopathic bacteria were examined for effects on osteoclast-like cell formation of bone marrow cells from lipopolysaccharide-responsive C3H-HeN and non-responsive C3H/HeJ mice. The...
Epidermal growth factor receptor (EGFR) is known to be localized early postnatally in the follicle of rat mandibular molars and to decline later. Here, EGFR mRNA present early postnatally in the follicle was revealed by in situ hybridization and reverse transcription-polymerase chain reaction....
This study was conducted to observe the differences between the adsorption of Streptococcus sanguis by saliva-coated and non-saliva-coated cells (plain cells) to the surfaces of saliva-coated, bovine serum albumin-coated or buffer-washed hydroxyapatite beads. Saliva treatment of bacterial cells...
Detailed knowledge of dentine structure, and especially that of the dentinal tubules, is essential in order to understand dentine permeability and to interpret data from investigations on dentine adhesive materials. The aim here was to examine the density and branching of dentinal tubules in...
Previous studies in man have relied only on electromyographic (EMG) activity patterns and anatomical landmarks to confirm electrode placement in the superior head of the lateral pterygoid. Computed tomography (CT) was used here to determine whether indwelling fine wires could be visualized in...
An animal model of bilirubinemia was used to determine whether bilirubin present in pigmented teeth can be extracted and qualitatively analysed. The bile ducts of 10 Long-Evans Agouti rats were ligated and bilirubin (14 mg/kg per day) was injected intraperitoneally for 4 days. When the animals...
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