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Mice lacking all three nitric oxide synthase (NOS) genes remain viable even though deletion of the major downstream target of NO, soluble guanylyl cyclase, is associated with a dramatically shortened life expectancy. Moreover, findings of relatively normal flow responses in eNOS knockouts are...
Prohibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS). Our recent findings suggest that high levels of oxidants in human...
Aims: Reactive oxygen species released from neutrophils during vascular inflammation could contribute to endothelial dysfunction seen in diseases such as atherosclerosis. Activated neutrophils generate hydrogen peroxide (H 2 O 2 ) and hypochlorous acid (HOCl), as well as chloramines that are...
Aims: The initiation of hypoxic pulmonary vasoconstriction (HPV) involves an increase in cytosolic calcium ((Ca 2+ ) i ) in pulmonary artery (PA) smooth muscle cells (PASMCs). Both the processes depend on extracellular Ca 2+ . Extracellular Ca 2+ can be sensed by extracellular calcium-sensing...
Background: The Renin-Angiotensin-Aldosterone-System plays a pivotal role in hypertension. Angiotensin II (Ang II) is a major regulator of aldosterone synthesis and secretion, and it is known to facilitate reactive oxygen species (ROS) generation in many cell types. Aims: Here, we assessed the...
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