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Background: Advanced gastric cancer has a poor prognosis, with a relative 5-year survival rate of 7%–27%. Chemotherapy, which improves overall survival (OS) and quality of life, is the main treatment option. Although numerous regimens have been investigated, there is no standard treatment....
Background: The antitumor activity of CS-1008, a humanized agonistic anti-human death receptor (DR) 5 antibody, was investigated in preclinical models. Materials and methods: Cytotoxicity of CS-1008 was evaluated in a several human tumor cell lines as well as primary human hepatocytes in vitro ....
Objective: The objective of this study was to assess the performance of three staging systems (Okuda, Cancer of the Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer group (BCLC)), for predicting survival in patients with hepatocellular carcinoma (HCC) and to explore how to improve...
ADAM-17 is a matrix metalloproteinase-like enzyme involved in the release of several ligands that have been shown to promote both cancer formation and progression. These ligands include transforming growth factor-α, amphiregulin, heparin-binding epidermal growth factor, epiregulin and tumor...
Background: Discovery of key proliferative and/or survival cascades closely linked to the biological effects of human epidermal growth factor receptor (HER) 1 ( erb B-1) and/or HER2 ( erb B-2) inhibitors may identify a priori mechanisms responsible for the development of acquired resistance in...
Patients and methods: We present a retrospective analysis of 99 consecutive patients with relapsed non-Hodgkin's lymphomas who were older than 65 years at the time of high-dose chemotherapy and autologous progenitor cell transplantation. Results: Median age at transplant was 68 years (range...
Background: The aim of this study was to identify prognostic factors for local and systemic failure after isolated hepatic perfusion (IHP) with 200 mg melphalan in patients with colorectal liver metastases. Patients and methods: Hundred and fifty-four patients were selected for IHP and underwent...
Background: Since 1985 considerable changes have taken place in the early detection and treatment of breast cancer. We quantified breast cancer trends for 35 countries with populations mainly of European ancestry. Methods: Incidence data were extracted from cancer registries and mortality data...
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