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Background: Bendamustine, an alkylating agent with a nitrogen mustard group and a purine-like benzimidazol group, has been shown to be effective in several solid tumors and indolent non-Hodgkin’s lymphomas, but has not yet been studied for efficacy in aggressive lymphomas. Patients and methods:...
There is a clear rationale for using hyperthermia in cancer treatment. Treatment at temperatures between 40 and 44°C is cytotoxic for cells in an environment with a low pO 2 and low pH, conditions that are found specifically within tumour tissue, due to insufficient blood perfusion. Under such...
Background: This study examined the assessment of risk/benefit ratios for phase II cancer clinical trials by Institutional Review Board (IRB) members. Patients and methods: Semi-structured interviews were conducted with 53 IRB members from six research hospitals and specialized cancer centers in...
Background: Burkitt’s lymphoma (BL) is a rare and rapidly progressive form of B-cell non-Hodgkin’s lymphoma. Cyclophosphamide, vincristine, doxorubicin, high-dose methotrexate (CODOX-M)/ifosfamide, etoposide and high-dose cytarabine (IVAC) is a highly effective alternating non-cross-resistant...
Background: The influence of age on the outcome of follicular non-Hodgkin’s lymphoma (FL) was studied in a population-based non-Hodgkin’s lymphoma registry. Patients and methods: This study comprised 214 follicular lymphoma patients. Grade I/II was considered separately from grade III FL. The...
Background: Although the evaluation of new investigational drugs in phase I, II and III trials requires considerable time and patient resources, only a few of these drugs are ultimately established as anticancer drugs. Materials and methods: We collected papers of phase I trials by a Medline...
Combination of chemotherapy and surgical resection of metastases is the most promising strategy to improve the fraction of long-term survivors and cured patients in metastatic colorectal cancer. We reproducibly observed evidence of exacerbation of the oxaliplatin-induced neurosensory toxicity...
Background: The aim of this study was to explore the association between extent of cutaneous involvement, presenting features and progression-free survival (PFS) in patients with primary cutaneous non-Hodgkin’s lymphoma (PCNHL) of aggressive histology. Methods: Previously untreated patients...
Background: The cyclin D1/p16/Rb pathway plays a critical role in tumorigenesis and each component of this pathway may be affected in various malignancies. The purpose of this study was to investigate the expression and prognostic significance of these proteins in nasopharyngeal carcinoma (NPC)....
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