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Background. Based on randomized clinical trials, mortality of acute coronary syndrome (ACS) has been considered to be relatively low. The prognosis of clinical presentations of ACS in real‐life patient cohorts has not been well documented. Aim. The aim of this study was to evaluate actual...
Background. Various indexes of 24‐hour heart rate variability (HRV) have been able to predict all‐cause mortality after an acute myocardial infarction (AMI), but their value in predicting specific modes of cardiac death has been limited. Aim. The aim of this study was to assess the role of...
Scleroderma or systemic sclerosis (SSc) is a complex disease in which the vasculopathy and the activation of the immune system with production of inflammatory mediators lead to dysregulated fibroblast activation. The resulting excessive deposition of collagens and other extracellular matrix...
Breast cancer is the major malignancy among women in the Western world. The breast is clearly a target organ for sex steroid hormones and hormonal treatments have been associated with an increased risk of breast cancer. The balance between proliferation and apoptosis is important for breast cell...
Background. Platelet activation is involved in the pathogenesis of the thrombotic complications of hypertension. Novel surrogate markers of platelet activation (mean platelet volume (MPV), mean platelet component (MPC, measure of platelet density), platelet component distribution width (PCDW, a...
Calcium sensitizers are a new group of inotropic drugs. Levosimendan is the only calcium sensitizer in clinical use in Europe. Its mechanism of action includes both calcium sensitization of contractile proteins and the opening of adenosine triphosphate (ATP)‐dependent potassium channels as...
Since selective cyclooxygenase‐2 inhibitors (coxibs) entered the market, there has been concern about the cardiovascular safety of coxibs. In addition, recent data suggest that classical non‐steroidal anti‐inflammatory drugs (NSAIDs) have a similar cardiovascular risk. Importantly, all of...
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