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Type 2 diabetes (T2D) and obesity are recognized as conditions of growing biomedical importance to societies worldwide. Despite this, lack of understanding concerning the processes which normally serve to maintain weight and to regulate glucose concentrations, and ignorance about the mechanisms...
The human uterine cervix can produce nitric oxide (NO), a free radical with an ultra-short half-life. The release of NO changes during pregnancy and is increased in early nonviable pregnancies compared to normal uncomplicated pregnancies. This review concentrates on the role of NO release in...
Background. Adenosine triphosphate (ATP)-binding cassette transporter A3 ( ABCA3 ) gene mutations cause fatal respiratory failure in term infants, but common ABCA3 polymorphisms have remained uncharacterized at the population level. Aim. To define a subset of tagging single-nucleotide...
Background. Oxidative stress has a role in the pathogenesis of gastroesophageal reflux disease (GERD). Aim. To investigate the redox balance in proximal esophagus before and 6 and 48 months after antireflux surgery. Methods. In 20 GERD patients and 9 controls oxidative stress by myeloperoxidase...
Background. Different soluble molecules involved in inflammation, endothelial damage, or hemostasis are recognized as potential cardiovascular risk markers. Studies to assess the role of these markers in the atherosclerotic process by evaluating their relationship to carotid intima-media...
Countries undergoing the nutrition transition are experiencing a progressive increase in obesity and nutrition-related chronic diseases (NRCDs). In transitional countries, stunting (shortness for age) and micronutrient deficiencies (iron, vitamin A, and zinc) in children coexist with obesity and...
Background. The quantification of circulating endothelial cells (CECs) in whole blood is an increasingly recognized index of endothelial damage/dysfunction. Abnormal CECs have been linked to the severity of coronary artery disease (CAD). Objective . We assessed the relationship of CECs to other...
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