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Gerovital® was compared with placebo and another procaine preparation in a double blind study of 88 rehabilitation patients suffering from back or hip disease. In an open part of the study procaine from intramuscularly injected Gerovital® disappeared from the plasma within 15–30 minutes. In...
Substrate utilization during exercise is determined by the intensity and duration of exercise as well as by training status and the availability of substrate. The major energy source at rest and during low intensity exercise is fat oxidation while oxidation of carbohydrates and anaerobic energy...
Increased hepatic glucose output is the main cause of fasting hyperglycemia in non-insulin dependent diabetes mellitus. Due to difficulties in obtaining a quantitative estimate of gluconeogenesis in vivo , the relative contribution of gluconeogenesis and glycogenolysis to this increased hepatic...
The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96.6% of patients and 93.9% of controls with a metabolic ratio of debrisoquine < 12.6 were classified as extensive metabolizers of debrisoquine ( P = NS). The...
The rationale for pharmacologically increasing the transcription of the insulin responsive-glucose transporter of muscle and fat in diabetes is presented. The experimental approaches to achieve such a goal are outlined as well as a delineation of the assumptions and potential problems associated...
Patients with type 1 diabetes are characterized by an average 40% reduction in the insulin sensitivity. In newly diagnosed patients, insulin resistance is due to insulin deficiency and its metabolic consequences. After the beginning of insulin therapy, insulin sensitivity transiently improves,...
The life expectancy and quality of life of diabetic patients are largely determined by the long-term complications. Convincing evidence exists to show that the complications are secondary to the altered internal milieu caused by inappropriate insulin action—insulin deficiency in type 1 diabetes...
A variety of isotopic tracers can be used to quantitate glucose kinetics in vivo Using the standard approach to calculate the rate of appearance (Ra) of glucose from kinetic data, different rates of Ra glucose are obtained depending on the nature and position of the label in glucose. If total...
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