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This report describes the results of long-term treatment for blood lipid regulation with a new drug, gemfibrozil (Lopid®). During a short-term placebo-controlled phase, gemfibrozil had significantly reduced triglycerides, VLDL-cholesterol, and total LDL-cholesterol, and had significantly...
The effects of a nitrate coronary vasodilator, Pentaerythritol Tetranitrate (Peritrate®), on perfusion and function of ischemic heart muscle were studied in six patients. Coronary angiograms were performed on all subjects, and a high degree of triple-vessel disease was present in all. Our...
The results of the nutritional intervention on one of the twenty MRFIT centers is presented. The reduction in cholesterol was 5.78% after four years. Those results were compared with the changes found in serum cholesterol with a similar diet and the administration of either clofibrate or...
The effect of gemfibrozil, a new lipid-lowering agent, was studied in 22 patients. Each patient served as his own control in a double blind study. The administration of gemfibrozil, for a period of 24 months, 1200 mg daily, reduced mean serum triglyceride levels by 45.6% (p<0.001) and mean serum...
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