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Antibody light chains (LCs) comprise the most structurally diverse family of proteins involved in amyloidosis. Many antibody LCs incorporate structural features that impair their stability and solubility, leading to their assembly into fibrils and to their subsequent pathological deposition when...
Amyloid peptides are the major constituents of amyloid deposits in various amyloid diseases including Alzheimer's disease, type II diabetes mellitus, prion diseases and others. The hallmark of amyloid is the binding of the dye, Congo red, which creates characteristic staining due to the dye's...
The histochemical and immunohistochemical differential diagnosis of amyloidosis in surgical pathology in a referral center is presented. Different forms of amyloidosis are considered e.g. systemic generalized amyloidosis: secondary (AA), primary (AL), senile, hemodialysis-associated, hereditary...
The binding mechanism of Congo red (CR) to Alzheimer's disease (AD) amyloid fibrils (Aβ) in terms of binding affinity and number of sites was quantitated from absorption spectroscopy (at 200-700 nm) by measuring the concentration of CR bound (CR-B) to AD Aβ assemblies as a function of CR...
An Atlas of Alzheimer's Disease Edited by Mony J. deLeon The Parthenon Publishing Group Ltd., 1999 149 pages, $101.00 ISBN 1-85070-912-2
A form of beta-amyloid peptide Aβ ending at amino acid 42 (Aβ42) is the major component of senile amyloid plaques in Alzheimer's Disease (AD). The Aβ-peptide earliest modifications are extremely important since they constitute the key events in the progression towards further changes finally...
Synthetic amyloid β-protein (Aβ) is used widely to study fibril formation and the physiologic effects of low molecular weight and fibrillar forms of the peptide on cells in culture or in experimental animals. Not infrequently, conflicting results have arisen in these studies, in part due to...
A Dutch family with familial amyloidotic polyneuropathy associated with the transthyretin mutation VaUlAla is described. This is the third reported family with this mutation, causing at the protein level an unstable TTR monomer and at the clinical level progressive wasting, polyneuropathy,...
Amyloid precursor protein (AβPP) processing results in generation of amyloid β peptide (Aβ) which deposits in the brain parenchyma and cerebrovasculature of patients with Alzheimer's disease (AD). Evidence that the vascular deposits derive in part from AβPP fragments originating from...
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