Within the last year
Within the past 3 years
1 - 8 of 8 articles
We examined the transthyretin gene of a German individual by direct DNA sequencing and found a guanine to cytosine transversion at the first base ofcodon 74 which resulted in a replacement ofhistidinefor aspartic acid. This mutation was confirmed by restriction fragment length polymorphism...
Using differential affinity chromatography, antibodies were prepared to the carboxy-terminal and amino-terminal portions of murine SAA. Immunohistochemical examinations of spleen AA amyloid with these antibodies, at both the light and electron microscopic levels, indicated the presence of...
Acute phase protein concentrations have been advocated as objective biochemical measures of disease activity in rheumatoid arthritis. However, the relationship of changes in acute phase proteins to the biochemical, histologic and physiologic alterations of arthritic disease is not precisely...
A new kindred carrier of TTR Leu 64 is reported. The mutation, detected by PCR amplified DNA sequencing of the propositus, was diagnosed in other members of the family by PCR-RFLP analysis with the enzyme Apo I.
Amyloid deposits are associated with a variety of amyloid diseases, although their role in the pathogenesis remains unclear. Detection of amyloid fibrils and/or prevention of their formation appears to be important in the diagnosis and treatment of amyloid diseases such as Alzheimer's disease....
The amino acid sequence of raccoon islet amyloid polypeptide (IAPP), as predicted by analysis of polymerase chain reaction (PCR)-amplified sequences from genomic DNA, contains the same putative amyloidogenic sequence (GAILS) at residues 24-28 as human and cat IAPP. These findings are consistent...
A new test has been developed to detect the His 58 variant transthyretin allele associated with familial amyloidotic polyneuropathy type II in the Maryland/German kindreds. Since the point mutation identified in this disease does not alter the restriction pattern of the TTR gene, previous DNA...
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one.
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.