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A role for interferon- (IFN- ) has been implied in the atherogenic process. To determine whether exogenously administered IFN- exerts an effect on the development of atherosclerosis, we intraperitoneally administered either recombinant IFN- (100 U/g body weight) or phosphate buffered saline daily...
Intestinal biopsy in a boy with gastroenteritis-induced protein-losing enteropathy (PLE) showed loss of heparan sulfate (HS) and syndecan-1 core protein from the basolateral surface of the enterocytes, which improved after PLE subsided. Isoelectric focusing analysis of serum transferrin indicated...
The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes ( TAp63 ) or act as p53 -dominant-negatives ( Np63 ). p63 is expressed in the basal cells of many epithelial organs and its germline inactivation in the mouse results in agenesis of organs such as...