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Individual differences in cognitive function are highly heritable and most likely driven by multiple genes of small effect. Well‐characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine...
Declaring “replication” from results of genome wide association (GWA) studies is straightforward when major gene effects provide genome‐wide significance for association of the same allele of the same SNP in each of multiple independent samples. However, such unambiguous replication may be...
Insulin‐like growth factor 1 (IGF1) has been shown to have an important role in brain development and function. Studies of IGF1 administration in rodents have shown that it has an anxiolytic and antidepressant effect. A genome‐wide association study (GWAS) of the first University College...
Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole‐genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the responsible genes or variants in those regions...
In the past decade, we and others have consistently reported linkage to a schizophrenia (SZ) susceptibility region on chromosome 8p21. Most recently, in the largest SZ linkage sample to date, a multi‐site international collaboration performed a SNP‐based linkage scan (∼6,000 SNPs; 831...
The 16p11.2 deletion is a recurrent genomic event and a significant risk factor for autism spectrum disorders (ASD). This genomic disorder also exhibits extensive phenotypic variability and diverse clinical phenotypes. The full extent of phenotypic heterogeneity associated with the 16p11.2...
Autism spectrum disorders (ASDs) are a heterogeneous group of disorders with a complex genetic etiology. We used high‐resolution whole genome array‐based comparative genomic hybridization (array‐CGH) to screen 223 ASD patients for gene dose alterations associated with susceptibility for...
Biological and positional evidence supports the involvement of the GAD1 and distal‐less homeobox genes (DLXs) in the etiology of autism. We investigated 42 single nucleotide polymorphisms in these genes as risk factors for autism spectrum disorders (ASD) in a large family‐based association...
In the genome‐wide association study (GWAS) on schizophrenia (O'Donovan et al. (2008); Nat Genet 40:1053–1055) a UK‐sample of 479 cases with DSM‐IV schizophrenia was genotyped in comparison to control subjects with follow up of 12 putative loci in international replication sets of...
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