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Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder occurring in male and occasional female carriers of a premutation expansion (55–200 CGG repeats) of the fragile X mental retardation 1 gene (FMR1). This study assessed the relationship between hippocampal...
The reported interaction between the length polymorphism (5HTTLPR) in the serotonin transporter gene (SLC6A4) and stressful life events on depression has led to many attempts to replicate but with inconsistent results. This inconsistency may reflect, in part, small sample size and the unknown...
A large number of independent studies have reported evidence for association between the dysbindin gene (DTNBP1) and schizophrenia; however, specific risk alleles have been not been implicated as causal. In this study we set out to perform a comprehensive assessment of DNA variation within the...
Gene × environment (G × E) interactions mediating depressive symptoms have been separately identified in the stress‐sensitive serotonergic (5‐HTTLPR) and corticotropin‐releasing hormone (CRHR1) systems. Our objective was to examine whether the effects of child abuse are moderated by gene...
We performed a linkage analysis on 23 Finnish families with bipolar disorder and originating from the North‐Eastern region of Finland, using the Illumina Linkage Panel IV (6K) Array with an average intermarker spacing of 0.65 cM across the genome. We detected genome‐wide significant evidence...
Chromosome 18 abnormalities are associated with a range of physical abnormalities such as short stature and hearing impairments. Psychiatric manifestations have also been observed. This study focuses on the presentations of psychiatric syndromes as they relate to specific chromosomal...
Several studies have observed decreased expression of spermidine/spermine N1‐acetyltransferase (SAT1) in the brains of suicide completers, and we previously identified a single‐nucleotide polymorphism in the promoter region of SAT1 which was associated with suicide completion and SAT1...
Several previous genome‐wide and targeted association studies revealed that variants in the CHRNA5–CHRNA3–CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits of the nicotinic acetylcholine receptors (nAChRs) are associated with nicotine dependence...
Genetic linkage studies in bipolar disorder (BPD) suggest that a susceptibility locus exists on chromosome 18p11. The metallophosphoesterase (MPPE1) gene maps to this region. Dysregulation of protein phosphorylation and subsequent abnormal cellular signaling has been postulated to be involved in...
Genetic association studies have yielded extensive but frequently inconclusive data about genetic risk factors for schizophrenia. Clinical and genetic heterogeneity are possible factors explaining the inconsistent findings. The objective of this study was to test the association of commonly...
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